Keratins: A structural scaffold with emerging functions

J. Kirfel, T. M. Magin, J. Reichelt*

*Corresponding author for this work
130 Citations (Scopus)


Intermediate filament proteins form an essential part of the cytoskeleton and provide topological order to cells and tissues. These features result from their intrinsic property of self-organization and their response to extrinsic cues. Keratins represent the largest subgroup among all intermediate filament proteins and are differentially expressed as pairs of type I and type II intermediate filament proteins in epithelia. Their primary function is to impart mechanical strength to cells. This function is illustrated by patients with keratin mutations and by gene-deficient mice. Additional functions include their participation in the response to stress, cell signalling and apoptosis, and thus the keratin cytoskeleton appears far more dynamic than previously anticipated. This may result from hyperphosphorylation and possibly from interaction with associated proteins. How signalling networks affect keratin organization, turnover and function and vice versa will be a major challenge for future investigations.

Original languageEnglish
JournalCellular and Molecular Life Sciences
Issue number1
Pages (from-to)56-71
Number of pages16
Publication statusPublished - 01.01.2003


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