Keine assoziation zwischen p53-uberexpression und polarographisch gemessener tumoroxygenierung bei patienten mit kopf-hals-karzinomen

Translated title of the contribution: No association between p53-overexpression and polarographically measured tumor oxygenation in patients with head and neck carcinomas

Axel Becker*, Peter Stadler, Ulf Krause, Thomas Kuhnt, Gabriele Hänsgen, Peer Dettmar, Horst Jürgen Feldmann, Friedrich Wilhelm Rath, Michael Molls, Jürgen Dunst

*Corresponding author for this work
10 Citations (Scopus)

Abstract

Purpose: Clinical investigation Of a potential relationship between the polarographically measured tumor oxygenation and the p53 status in patients with squamous cell carcinoma of the head and neck. Patients and Methods: In 99 patients with mostly advanced, histologically proven squamous cell carcinoma of the head and neck we estimated the classical tumor parameters (TNM stage, histological grading) the immunohistochemical p53-overexpression (DO-7) and the tumor oxygenation status (Eppendorf pO2 Histograph). The tumor volume and the hemoglobin concentration were evaluated simultaneously. Results: No statistically significant difference could be detected between immunohistological p53-positive (p53 ≥ 10% stained cells) and p53-negative tumors (p53 < 10% stained cells) regarding both the median pO2 and the relative frequency of values ≤5 mm Hg. Moreover, no statistically relevant differences could be seen between both p53-groups considering the hemoglobin concentration, the TNM stage, the histological grading and the tumor volume. Conclusion: Our data imply that there is no association between p53-overexpression and tumor hypoxia in head and neck carcinomas. However, this is not necessarily in contradiction to experimental or clinical data that confirmed a relationship between hypoxia and p53-mediated increased malignancy of tumor cells in other tumor entities. The comparable oxygenation status of p53-positive and p53-negative tumors in our study is associated with an analogous clinical tumor aggressiveness of both groups. That could be caused by a hypoxia related but p53-independent selection of tumor cells with a more malignant phenotype in head and neck carcinomas. However, further research is needed to prove this possible relationship.

Translated title of the contributionNo association between p53-overexpression and polarographically measured tumor oxygenation in patients with head and neck carcinomas
Original languageGerman
JournalStrahlentherapie und Onkologie
Volume176
Issue number10
Pages (from-to)475-480
Number of pages6
ISSN0179-7158
DOIs
Publication statusPublished - 2000

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