Karzinom-in-Karzinom-Metastasierung eines amelanotischen Melanoms in ein Nierenzellkarzinom

Translated title of the contribution: Cancer-to-cancer metastasis: Amelanotic melanoma into renal cell carcinoma

F. Sayk*, A. Mahnken, F. Stellmacher, K. Dalhoff, H. Merz

*Corresponding author for this work
1 Citation (Scopus)


History and physical findings: A 54-year old man was admitted because of motor aphasia, behavioral changes and weight loss and suffered from a widely disseminated cancer with unknown primary origin (CUP) syndrome. Diagnosis: The autopsy revealed that he was affected by two malignant neoplasms simultaneously: an amelanotic malignant melanoma metastasizing into a localized renal cell carcinoma. Conclusion: Cancer-to-cancer metastasis is an exceedingly rare, but well documented phenomenon. This is the third reported case of a malignant melanoma as donor tumor spreading into a renal cell carcinoma. Well-vascularized and slowly growing renal tumors are typical recipients for cancer-to-cancer metastases. The amelanotic character of the melanoma exerted a special diagnostic challenge. Clinical and autopsy findings as well as the immunophenotypical features of the metastatic amelanotic melanoma (HMB-45, Melan-A/MART-1, S100) and the renal cell carcinoma are described with a review of the relevant literature.

Translated title of the contributionCancer-to-cancer metastasis: Amelanotic melanoma into renal cell carcinoma
Original languageGerman
JournalDeutsche Medizinische Wochenschrift
Issue number11
Pages (from-to)507-510
Number of pages4
Publication statusPublished - 19.03.2010


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