JUVENILE LINEARE IGA-DERMATOSE MOGLICHKEITEN DER DIAGNOSTIK

B. Jorg; H. Hamm; M. Dmochowski; T. Hashimoto; E. B. Brocker; D. Zillikens

JUVENILE LINEARE IGA-DERMATOSE MOGLICHKEITEN DER DIAGNOSTIK

Translated title of the contribution: Juvenile linear IgA disease: Diagnostic options

B. Jorg^*, H. Hamm, M. Dmochowski, T. Hashimoto, E. B. Brocker, D. Zillikens

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

University of Würzburg

1 Citation (Scopus)

Abstract

An 18-month-old girl presented with an eruption of tense blisters on the face, oral mucous membranes, arms and legs arising over the past 3 weeks. Histologically, we found a subepidermal blister formation. Direct immunofluorescence demonstrated a linear deposition of IgA at the basement membrane zone. The indirect immunofluorescence with NaCl-separated human skin as a substrate revealed circulating IgA serum antibodies binding to the roof of the artificial blister. By immunoblotting of epidermal and dermal extracts, the antibodies recognized an epidermal protein of 97 kD. Three years later, the disease still requires oral treatment with dapsone and low-dose corticosteroids to suppress new blister formation.

Translated title of the contribution	Juvenile linear IgA disease: Diagnostic options
Original language	German
Journal	H+G Zeitschrift fur Hautkrankheiten
Volume	70
Issue number	3
Pages (from-to)	185-188
Number of pages	4
ISSN	0301-0481
Publication status	Published - 1995

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@article{91f889eda3e2427f8d1b07b7e1d9ebe5,

title = "JUVENILE LINEARE IGA-DERMATOSE MOGLICHKEITEN DER DIAGNOSTIK",

abstract = "An 18-month-old girl presented with an eruption of tense blisters on the face, oral mucous membranes, arms and legs arising over the past 3 weeks. Histologically, we found a subepidermal blister formation. Direct immunofluorescence demonstrated a linear deposition of IgA at the basement membrane zone. The indirect immunofluorescence with NaCl-separated human skin as a substrate revealed circulating IgA serum antibodies binding to the roof of the artificial blister. By immunoblotting of epidermal and dermal extracts, the antibodies recognized an epidermal protein of 97 kD. Three years later, the disease still requires oral treatment with dapsone and low-dose corticosteroids to suppress new blister formation.",

author = "B. Jorg and H. Hamm and M. Dmochowski and T. Hashimoto and Brocker, {E. B.} and D. Zillikens",

year = "1995",

language = "Deutsch",

volume = "70",

pages = "185--188",

journal = "H+G Zeitschrift fur Hautkrankheiten",

issn = "0301-0481",

number = "3",

}

TY - JOUR

T1 - JUVENILE LINEARE IGA-DERMATOSE MOGLICHKEITEN DER DIAGNOSTIK

AU - Jorg, B.

AU - Hamm, H.

AU - Dmochowski, M.

AU - Hashimoto, T.

AU - Brocker, E. B.

AU - Zillikens, D.

PY - 1995

Y1 - 1995

N2 - An 18-month-old girl presented with an eruption of tense blisters on the face, oral mucous membranes, arms and legs arising over the past 3 weeks. Histologically, we found a subepidermal blister formation. Direct immunofluorescence demonstrated a linear deposition of IgA at the basement membrane zone. The indirect immunofluorescence with NaCl-separated human skin as a substrate revealed circulating IgA serum antibodies binding to the roof of the artificial blister. By immunoblotting of epidermal and dermal extracts, the antibodies recognized an epidermal protein of 97 kD. Three years later, the disease still requires oral treatment with dapsone and low-dose corticosteroids to suppress new blister formation.

AB - An 18-month-old girl presented with an eruption of tense blisters on the face, oral mucous membranes, arms and legs arising over the past 3 weeks. Histologically, we found a subepidermal blister formation. Direct immunofluorescence demonstrated a linear deposition of IgA at the basement membrane zone. The indirect immunofluorescence with NaCl-separated human skin as a substrate revealed circulating IgA serum antibodies binding to the roof of the artificial blister. By immunoblotting of epidermal and dermal extracts, the antibodies recognized an epidermal protein of 97 kD. Three years later, the disease still requires oral treatment with dapsone and low-dose corticosteroids to suppress new blister formation.

UR - http://www.scopus.com/inward/record.url?scp=0028920342&partnerID=8YFLogxK

M3 - Zeitschriftenaufsätze

AN - SCOPUS:0028920342

SN - 0301-0481

VL - 70

SP - 185

EP - 188

JO - H+G Zeitschrift fur Hautkrankheiten

JF - H+G Zeitschrift fur Hautkrankheiten

IS - 3

ER -

JUVENILE LINEARE IGA-DERMATOSE MOGLICHKEITEN DER DIAGNOSTIK

Abstract

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