TY - JOUR
T1 - Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
AU - Huth, Cornelia
AU - Illig, Thomas
AU - Herder, Christian
AU - Gieger, Christian
AU - Grallert, Harald
AU - Vollmert, Caren
AU - Rathmann, Wolfgang
AU - Hamid, Yasmin H.
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Thorand, Barbara
AU - Meisinger, Christa
AU - Döring, Angela
AU - Klopp, Norman
AU - Gohlke, Henning
AU - Lieb, Wolfgang
AU - Hengstenberg, Christian
AU - Lyssenko, Valeriya
AU - Groop, Leif
AU - Ireland, Helen
AU - Stephens, Jeffrey W.
AU - Wernstedt Asterholm, Ingrid
AU - Jansson, John Olov
AU - Boeing, Heiner
AU - Möhlig, Matthias
AU - Stringham, Heather M.
AU - Boehnke, Michael
AU - Tuomilehto, Jaakko
AU - Fernandez-Real, Jose Manuel
AU - Lopez-Bermejo, Abel
AU - Gallart, Luis
AU - Vendrell, Joan
AU - Humphries, Steve E.
AU - Kronenberg, Florian
AU - Wichmann, H. Erich
AU - Heid, Iris M.
PY - 2009/3/5
Y1 - 2009/3/5
N2 - Background. Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
AB - Background. Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G>C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G>C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G>C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.
UR - http://www.scopus.com/inward/record.url?scp=61349133510&partnerID=8YFLogxK
U2 - 10.1080/07853890802337037
DO - 10.1080/07853890802337037
M3 - Journal articles
C2 - 18752089
AN - SCOPUS:61349133510
SN - 0785-3890
VL - 41
SP - 128
EP - 138
JO - Annals of Medicine
JF - Annals of Medicine
IS - 2
ER -
