TY - JOUR
T1 - Isolation and characterization of novel CAG repeat containing genes expressed in human brain
AU - Zühlke, Christine
AU - Kiehl, Rasmus
AU - Johannsmeyer, Antje
AU - Grzeschik, Karl Heinz
AU - Schwinger, Eberhard
N1 - Funding Information:
This work was supported by the Forschungs-forderungsprogramm der Medizinischen Uni- versitat Lubeck (89/96). Ch. Z. wish to thank Prof. Dr. W. Engel (Gottingen) for continous support, Dr. 0. Riess (Bochum) for helpful discussions, and S. Herlt, K. Schulz, S. Wagner, Institut fiir Humangenetik in Gottingen, J. Leu-telt and H. Bottger, Institut fur Humangenetik in Lubeck, for excellent technical assistance.
PY - 1999
Y1 - 1999
N2 - Neurodegenerative diseases may be caused by expansion of triplet repeats in human genes. To identify novel genes with CAG repeats, we screened a human brain cDNA library with an oligonucleotide probe. Four of the isolated cDNAs were sequenced, analyzed for polymorphisms, chromosomal localization, evolutionary conservation and expression. One of the repeats is bi-allelic with 10 triplets (80 % of chromosomes) and 7 triplets (20 % of chromosomes). In one of the genes two CAG repeats coding for 10 and 17 glutamines are localized in the same reading frame.
AB - Neurodegenerative diseases may be caused by expansion of triplet repeats in human genes. To identify novel genes with CAG repeats, we screened a human brain cDNA library with an oligonucleotide probe. Four of the isolated cDNAs were sequenced, analyzed for polymorphisms, chromosomal localization, evolutionary conservation and expression. One of the repeats is bi-allelic with 10 triplets (80 % of chromosomes) and 7 triplets (20 % of chromosomes). In one of the genes two CAG repeats coding for 10 and 17 glutamines are localized in the same reading frame.
UR - http://www.scopus.com/inward/record.url?scp=0344223299&partnerID=8YFLogxK
U2 - 10.3109/10425179909033929
DO - 10.3109/10425179909033929
M3 - Journal articles
C2 - 10565538
AN - SCOPUS:0344223299
SN - 1940-1736
VL - 10
SP - 1
EP - 6
JO - Mitochondrial DNA
JF - Mitochondrial DNA
IS - 1
ER -