IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups

Ashraf A. Elghzaly; Shereen S. Metwally; Farha A. El-Chennawi; Maha A. Elgayaar; Youssef M. Mosaad; Ehab E. El-Toraby; Mohsen M. Hegab; Saleh M. Ibrahim

doi:10.1016/j.humimm.2015.06.001

IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups

Ashraf A. Elghzaly^*, Shereen S. Metwally, Farha A. El-Chennawi, Maha A. Elgayaar, Youssef M. Mosaad, Ehab E. El-Toraby, Mohsen M. Hegab, Saleh M. Ibrahim

^*Corresponding author for this work

25 Citations (Scopus)

Abstract

Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association with IRF5 (p<. 0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.

Original language	English
Journal	Human Immunology
Volume	76
Issue number	7
Pages (from-to)	525-531
Number of pages	7
ISSN	0198-8859
DOIs	https://doi.org/10.1016/j.humimm.2015.06.001
Publication status	Published - 01.01.2015

Funding

The authors would like to thank Miriam Freitag for technical assistance. The study was supported by grants from the German Science Foundation (ExC306/1) and BMBF (IMPAM) to Saleh M. Ibrahim. First author received support from the Mansoura University , Egypt and the DAAD , Germany. Appendix A

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Elghzaly, A. A., Metwally, S. S., El-Chennawi, F. A., Elgayaar, M. A., Mosaad, Y. M., El-Toraby, E. E., Hegab, M. M., & Ibrahim, S. M. (2015). IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups. Human Immunology, 76(7), 525-531. https://doi.org/10.1016/j.humimm.2015.06.001

@article{76a78d6a3ff246bfae369c06a604559b,

title = "IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups",

abstract = "Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association with IRF5 (p<. 0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.",

author = "Elghzaly, \{Ashraf A.\} and Metwally, \{Shereen S.\} and El-Chennawi, \{Farha A.\} and Elgayaar, \{Maha A.\} and Mosaad, \{Youssef M.\} and El-Toraby, \{Ehab E.\} and Hegab, \{Mohsen M.\} and Ibrahim, \{Saleh M.\}",

year = "2015",

month = jan,

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doi = "10.1016/j.humimm.2015.06.001",

language = "English",

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Elghzaly, AA, Metwally, SS, El-Chennawi, FA, Elgayaar, MA, Mosaad, YM, El-Toraby, EE, Hegab, MM & Ibrahim, SM 2015, 'IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups', Human Immunology, vol. 76, no. 7, pp. 525-531. https://doi.org/10.1016/j.humimm.2015.06.001

IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups. / Elghzaly, Ashraf A.; Metwally, Shereen S.; El-Chennawi, Farha A. et al.
In: Human Immunology, Vol. 76, No. 7, 01.01.2015, p. 525-531.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups

AU - Elghzaly, Ashraf A.

AU - Metwally, Shereen S.

AU - El-Chennawi, Farha A.

AU - Elgayaar, Maha A.

AU - Mosaad, Youssef M.

AU - El-Toraby, Ehab E.

AU - Hegab, Mohsen M.

AU - Ibrahim, Saleh M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association with IRF5 (p<. 0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.

AB - Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association with IRF5 (p<. 0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.

UR - https://www.scopus.com/pages/publications/84941262485

U2 - 10.1016/j.humimm.2015.06.001

DO - 10.1016/j.humimm.2015.06.001

M3 - Journal articles

C2 - 26092158

AN - SCOPUS:84941262485

SN - 0198-8859

VL - 76

SP - 525

EP - 531

JO - Human Immunology

JF - Human Immunology

IS - 7

ER -

IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups

Abstract

Funding

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