TY - JOUR
T1 - IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups
AU - Elghzaly, Ashraf A.
AU - Metwally, Shereen S.
AU - El-Chennawi, Farha A.
AU - Elgayaar, Maha A.
AU - Mosaad, Youssef M.
AU - El-Toraby, Ehab E.
AU - Hegab, Mohsen M.
AU - Ibrahim, Saleh M.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association with IRF5 (p<. 0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.
AB - Objective: To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility. Methods: 170 Egyptian patients from Egypt Delta with SLE and 241 matched healthy controls were genotyped by Taqman real time PCR for the selected SNPs. Results: The results revealed significant association with IRF5 (p<. 0.0001) and PTPN22 (p=0.008) and insignificant association with KIF5A, CD28, IL2RA, BLK and TNFAIP3 genes. Conclusions: This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.
UR - http://www.scopus.com/inward/record.url?scp=84941262485&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2015.06.001
DO - 10.1016/j.humimm.2015.06.001
M3 - Journal articles
C2 - 26092158
AN - SCOPUS:84941262485
SN - 0198-8859
VL - 76
SP - 525
EP - 531
JO - Human immunology
JF - Human immunology
IS - 7
ER -