TY - JOUR
T1 - Investigation of the physical and psychosocial outcomes after living kidney donation - A multicenter cohort study (SoLKiD - Safety of Living Kidney Donors)
AU - Suwelack, Barbara
AU - Wörmann, Viktoriya
AU - Berger, Klaus
AU - Gerß, Joachim
AU - Wolters, Heiner
AU - Vitinius, Frank
AU - Burgmer, Markus
AU - Mühlfeld, Anja S.
AU - Halleck, Fabian
AU - Budde, Klemens
AU - Reinke, Petra
AU - Sefrin, Anett
AU - Wahba, Roger
AU - Hugo, Christian
AU - Opgenoorth, Mirian
AU - Woznowski, Magdalena
AU - Hansen, Anita
AU - Kribben, Andreas
AU - Witzke, Oliver
AU - Platschek, Steffen
AU - Hauser, Ingeborg A.
AU - Weimer, Rolf
AU - Rainer, Lucy
AU - Weigand, Karl
AU - Theil, Gerit
AU - Kroencke, Sylvia
AU - Koch, Martina
AU - Schiffer, Mario
AU - Lehner, Frank
AU - Zeier, Martin
AU - Sommerer, Claudia
AU - Rath, Thomas
AU - Papadopoulos, Georgios
AU - Feldkamp, Thorsten
AU - Fülbier, Astrid
AU - Nitschke, Martin
AU - Schlieter, Jessika
AU - Schamberger, Beate
AU - Lutz, Jens
AU - Nowak, Kai
AU - Krüger, Bernd
AU - Kirchner, Manuela
AU - Lopau, Kai
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/4/10
Y1 - 2018/4/10
N2 - Background: Over the last years, living kidney donation (LKD) has been established for patients with endstage renal failure as an alternative to post mortem donation, which is limited by organ scarcity and long lasting waiting periods. From an ethical perspective, the increase in LKD requires that donors' physical, psychological, and social harm has to be minimized as much as possible and the risk should not exceed the generally expected consequences of nephrectomy. Despite of numerous, mainly retrospective studies about the postoperative outcome of LKD over the last years from different countries, it becomes apparent that there is a lack of comprehensive prospective multicenter research in this field worldwide. Therefore, the main aim of the study is to examine the physical and psychosocial outcome of living kidney donors in a prospective design before and after transplantation in an interdisciplinary approach (surgery, nephrology, psychosocial medicine). Methods/design: The goal of the study is to investigate such aspects as the impact of gender- and age-specific factors on LKD outcome, donor outcome in correlation to the health status of the recipient, the medical and psychosocial risk of a healthy subject undergoing the LKD procedure. The study is carried out as a nationwide multicenter study. All adult living kidney donors with sufficient knowledge in the German, Russian, or Turkish language, informed consent, and place of residence in Germany are included. In a naturalistic design (cohort study), clinical data and self-report measures (questionnaires) of 320 donors are collected before and 8 weeks, 6 and 12 months after donation. Primary outcome parameters are the kidney function (estimated GFR) and the quality of life (SF-36) of the donor. Secondary outcome parameters are data about physical (e.g., wound healing, blood pressure) and psychosocial (fatigue, depression, anxiety, somatization) outcome after donation. Discussion: Previous studies on the postoperative outcome of living kidney donors have methodological limitations and/or were carried out in countries with different healthcare systems, e.g. United States, Norway, Canada, United Kingdom. Thus, results cannot be generalized and are not particularly applicable to the risks of mainly caucasian living kidney donors in the German healthcare system. The study design overcomes these disadvantages in that it provides a prospective multicenter design. Trial registration: German Clinical Trials Register DRKS00006552 (22 September 2014).
AB - Background: Over the last years, living kidney donation (LKD) has been established for patients with endstage renal failure as an alternative to post mortem donation, which is limited by organ scarcity and long lasting waiting periods. From an ethical perspective, the increase in LKD requires that donors' physical, psychological, and social harm has to be minimized as much as possible and the risk should not exceed the generally expected consequences of nephrectomy. Despite of numerous, mainly retrospective studies about the postoperative outcome of LKD over the last years from different countries, it becomes apparent that there is a lack of comprehensive prospective multicenter research in this field worldwide. Therefore, the main aim of the study is to examine the physical and psychosocial outcome of living kidney donors in a prospective design before and after transplantation in an interdisciplinary approach (surgery, nephrology, psychosocial medicine). Methods/design: The goal of the study is to investigate such aspects as the impact of gender- and age-specific factors on LKD outcome, donor outcome in correlation to the health status of the recipient, the medical and psychosocial risk of a healthy subject undergoing the LKD procedure. The study is carried out as a nationwide multicenter study. All adult living kidney donors with sufficient knowledge in the German, Russian, or Turkish language, informed consent, and place of residence in Germany are included. In a naturalistic design (cohort study), clinical data and self-report measures (questionnaires) of 320 donors are collected before and 8 weeks, 6 and 12 months after donation. Primary outcome parameters are the kidney function (estimated GFR) and the quality of life (SF-36) of the donor. Secondary outcome parameters are data about physical (e.g., wound healing, blood pressure) and psychosocial (fatigue, depression, anxiety, somatization) outcome after donation. Discussion: Previous studies on the postoperative outcome of living kidney donors have methodological limitations and/or were carried out in countries with different healthcare systems, e.g. United States, Norway, Canada, United Kingdom. Thus, results cannot be generalized and are not particularly applicable to the risks of mainly caucasian living kidney donors in the German healthcare system. The study design overcomes these disadvantages in that it provides a prospective multicenter design. Trial registration: German Clinical Trials Register DRKS00006552 (22 September 2014).
UR - http://www.scopus.com/inward/record.url?scp=85045212964&partnerID=8YFLogxK
U2 - 10.1186/s12882-018-0871-z
DO - 10.1186/s12882-018-0871-z
M3 - Journal articles
C2 - 29631543
AN - SCOPUS:85045212964
SN - 1471-2369
VL - 19
JO - BMC Nephrology
JF - BMC Nephrology
IS - 1
M1 - 83
ER -