Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

Kerstin U. Ludwig; Darina Roeske; Johannes Schumacher; Gerd Schulte-Körne; Inke R. König; Andreas Warnke; Ellen Plume; Andreas Ziegler; Helmut Remschmidt; Bertram Müller-Myhsok; Markus M. Nöthen; Per Hoffmann

doi:10.1007/s00702-008-0124-6

Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

Kerstin U. Ludwig, Darina Roeske, Johannes Schumacher, Gerd Schulte-Körne, Inke R. König, Andreas Warnke, Ellen Plume, Andreas Ziegler, Helmut Remschmidt, Bertram Müller-Myhsok, Markus M. Nöthen, Per Hoffmann^*

^*Corresponding author for this work

Institute of Medical Biometry and Statistic

41 Citations (Scopus)

Abstract

The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.

Original language	English
Journal	Journal of Neural Transmission
Volume	115
Issue number	11
Pages (from-to)	1587-1589
Number of pages	3
ISSN	0300-9564
DOIs	https://doi.org/10.1007/s00702-008-0124-6
Publication status	Published - 11.2008

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Ludwig, K. U., Roeske, D., Schumacher, J., Schulte-Körne, G., König, I. R., Warnke, A., Plume, E., Ziegler, A., Remschmidt, H., Müller-Myhsok, B., Nöthen, M. M., & Hoffmann, P. (2008). Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. Journal of Neural Transmission, 115(11), 1587-1589. https://doi.org/10.1007/s00702-008-0124-6

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title = "Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample",

abstract = "The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension {"}word reading{"}, the core phenotype in the study of Harold et al., which may be considered as supportive evidence.",

author = "Ludwig, {Kerstin U.} and Darina Roeske and Johannes Schumacher and Gerd Schulte-K{\"o}rne and K{\"o}nig, {Inke R.} and Andreas Warnke and Ellen Plume and Andreas Ziegler and Helmut Remschmidt and Bertram M{\"u}ller-Myhsok and N{\"o}then, {Markus M.} and Per Hoffmann",

note = "Funding Information: GSK, AW, AZ, HR, BMM and MMN were supported by the Deutsche Forschungsgemeinschaft. MMN received further support for this work from the Alfried Krupp von Bohlen und Halbach-Stiftung. The study was approved by the ethical committees of the Universities of Marburg and W{\"u}rzburg. Informed consent was given by all participants or their parents if aged 14 or younger. ",

year = "2008",

month = nov,

doi = "10.1007/s00702-008-0124-6",

language = "English",

volume = "115",

pages = "1587--1589",

journal = "Journal of Neural Transmission",

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T1 - Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

AU - Ludwig, Kerstin U.

AU - Roeske, Darina

AU - Schumacher, Johannes

AU - Schulte-Körne, Gerd

AU - König, Inke R.

AU - Warnke, Andreas

AU - Plume, Ellen

AU - Ziegler, Andreas

AU - Remschmidt, Helmut

AU - Müller-Myhsok, Bertram

AU - Nöthen, Markus M.

AU - Hoffmann, Per

N1 - Funding Information: GSK, AW, AZ, HR, BMM and MMN were supported by the Deutsche Forschungsgemeinschaft. MMN received further support for this work from the Alfried Krupp von Bohlen und Halbach-Stiftung. The study was approved by the ethical committees of the Universities of Marburg and Würzburg. Informed consent was given by all participants or their parents if aged 14 or younger.

PY - 2008/11

Y1 - 2008/11

N2 - The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.

AB - The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.

UR - http://www.scopus.com/inward/record.url?scp=55349131289&partnerID=8YFLogxK

U2 - 10.1007/s00702-008-0124-6

DO - 10.1007/s00702-008-0124-6

M3 - Journal articles

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SN - 0300-9564

VL - 115

SP - 1587

EP - 1589

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 11

ER -

Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

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