Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

Tabea Kohlfaerber; Shujun Ding; Ramtin Rahmanzadeh; Thomas Jüngst; Jürgen Groll; Hinnerk Schulz-Hildebrandt; Gereon Hüttmann

doi:10.18416/AMMM.2019.1909S03P19

Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

Tabea Kohlfaerber, Shujun Ding, Ramtin Rahmanzadeh, Thomas Jüngst, Jürgen Groll, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann

University of Würzburg

Abstract

Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.

Original language	English
Journal	Transactions on Additive Manufacturing Meets Medicine
Volume	1
Issue number	1
Pages (from-to)	1-2
Number of pages	2
DOIs	https://doi.org/10.18416/AMMM.2019.1909S03P19
Publication status	Published - 12.09.2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Research Areas and Centers

Academic Focus: Biomedical Engineering

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10.18416/AMMM.2019.1909S03P19

Cite this

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abstract = "Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.",

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AU - Kohlfaerber, Tabea

AU - Ding, Shujun

AU - Rahmanzadeh, Ramtin

AU - Jüngst, Thomas

AU - Groll, Jürgen

AU - Schulz-Hildebrandt, Hinnerk

AU - Hüttmann, Gereon

PY - 2019/9/12

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N2 - Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.

AB - Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.

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Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

Abstract

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