Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT

Tabea Kohlfaerber, Shujun Ding, Ramtin Rahmanzadeh, Thomas Jüngst, Jürgen Groll, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann

Abstract

Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.
Original languageEnglish
JournalTransactions on Additive Manufacturing Meets Medicine
Volume1
Issue number1
Pages (from-to)1-2
Number of pages2
DOIs
Publication statusPublished - 12.09.2019

Research Areas and Centers

  • Academic Focus: Biomedical Engineering

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