TY - JOUR
T1 - Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT
AU - Kohlfaerber, Tabea
AU - Ding, Shujun
AU - Rahmanzadeh, Ramtin
AU - Jüngst, Thomas
AU - Groll, Jürgen
AU - Schulz-Hildebrandt, Hinnerk
AU - Hüttmann, Gereon
PY - 2019/9/12
Y1 - 2019/9/12
N2 - Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.
AB - Optical coherence tomography (OCT) is a non-invasive and label-free imaging modality based on the detection of backscattered light in biological samples. As microscopic OCT (mOCT) combines high axial and lateral resolution by using a supercontinuum light source and a high numerical aperture objective, an investigation of biological and printed samples at subcellular level is feasible. The additional excellent depth resolution enables mOCT to be a suitable quality control of 3D printed samples. The use of speckle variance (SV) adds information about cell viability. Here we present the feasibility of investigating cell viability within a cell spheroid and monitoring the cell interaction with bioprinted scaffolds using mOCT.
UR - https://www.mendeley.com/catalogue/31d1534d-2605-3b58-ad67-d06c83b34e0e/
U2 - 10.18416/AMMM.2019.1909S03P19
DO - 10.18416/AMMM.2019.1909S03P19
M3 - Journal articles
VL - 1
SP - 1
EP - 2
JO - Transactions on Additive Manufacturing Meets Medicine
JF - Transactions on Additive Manufacturing Meets Medicine
IS - 1
ER -