Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study

Philipp Kosian; Astrid Hellmund; Annegret Geipel; Rainer Bald; Otilia Maria Geist; Paul Böckenhoff; Jorge Jimenez-Cruz; Maria Deja; Brigitte Strizek; Christoph Berg; Ulrich Gembruch

doi:10.1007/s00404-022-06712-z

Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study

Philipp Kosian^*, Astrid Hellmund, Annegret Geipel, Rainer Bald, Otilia Maria Geist, Paul Böckenhoff, Jorge Jimenez-Cruz, Maria Deja, Brigitte Strizek, Christoph Berg, Ulrich Gembruch

^*Corresponding author for this work

Clinic of Anesthesiology

Abstract

Purpose: Evaluating procedure-related complications and perinatal outcomes after intrauterine transfusion (IUT) before or after 20⁺⁰ weeks of gestation in fetuses with severe anemia due to intrauterine human parvovirus B19 infection. Methods: A retrospective study investigating fetuses requiring IUT for fetal Parvo B19 infection in two tertiary referral centers between December 2002 and December 2021. Procedure-related complications, intrauterine fetal death (IUFD), and perinatal outcome were correlated to gestational age (GA) at first IUT, the presence of hydrops and fetal blood sampling results. Results: A total of 186 IUTs were performed in 103 fetuses. The median GA at first IUT was 19⁺³ (13⁺⁰–31⁺⁴) weeks of gestation. IUFD occurred in 16/103 fetuses (15.5%). Overall survival was 84.5% (87/103). Hydrops (p = 0.001), lower mean hemoglobin at first IUT (p = 0.001) and low platelets (p = 0.002) were strongly associated with IUFD. There was no difference observed in fetuses transfused before or after 20⁺⁰ weeks of gestation. Conclusion: IUT is a successful treatment option in fetuses affected by severe anemia due to parvovirus B19 infection in specialized centers. In experienced hands, IUT before 20 weeks is not related to worse perinatal outcome.

Original language	English
Journal	Archives of Gynecology and Obstetrics
Volume	308
Issue number	1
Pages (from-to)	117-125
Number of pages	9
ISSN	0932-0067
DOIs	https://doi.org/10.1007/s00404-022-06712-z
Publication status	Published - 07.2023

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

2.21-04 Virology
2.21-05 Immunology
2.22-21 Gynaecology and Obstetrics
2.22-31 Clinical Infectiology and Tropical Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00404-022-06712-z

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Kosian, P., Hellmund, A., Geipel, A., Bald, R., Geist, O. M., Böckenhoff, P., Jimenez-Cruz, J., Deja, M., Strizek, B., Berg, C., & Gembruch, U. (2023). Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study. Archives of Gynecology and Obstetrics, 308(1), 117-125. https://doi.org/10.1007/s00404-022-06712-z

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title = "Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study",

abstract = "Purpose: Evaluating procedure-related complications and perinatal outcomes after intrauterine transfusion (IUT) before or after 20+0 weeks of gestation in fetuses with severe anemia due to intrauterine human parvovirus B19 infection. Methods: A retrospective study investigating fetuses requiring IUT for fetal Parvo B19 infection in two tertiary referral centers between December 2002 and December 2021. Procedure-related complications, intrauterine fetal death (IUFD), and perinatal outcome were correlated to gestational age (GA) at first IUT, the presence of hydrops and fetal blood sampling results. Results: A total of 186 IUTs were performed in 103 fetuses. The median GA at first IUT was 19+3 (13+0–31+4) weeks of gestation. IUFD occurred in 16/103 fetuses (15.5%). Overall survival was 84.5% (87/103). Hydrops (p = 0.001), lower mean hemoglobin at first IUT (p = 0.001) and low platelets (p = 0.002) were strongly associated with IUFD. There was no difference observed in fetuses transfused before or after 20+0 weeks of gestation. Conclusion: IUT is a successful treatment option in fetuses affected by severe anemia due to parvovirus B19 infection in specialized centers. In experienced hands, IUT before 20 weeks is not related to worse perinatal outcome.",

author = "Philipp Kosian and Astrid Hellmund and Annegret Geipel and Rainer Bald and Geist, {Otilia Maria} and Paul B{\"o}ckenhoff and Jorge Jimenez-Cruz and Maria Deja and Brigitte Strizek and Christoph Berg and Ulrich Gembruch",

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year = "2023",

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doi = "10.1007/s00404-022-06712-z",

language = "English",

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Kosian, P, Hellmund, A, Geipel, A, Bald, R, Geist, OM, Böckenhoff, P, Jimenez-Cruz, J, Deja, M, Strizek, B, Berg, C & Gembruch, U 2023, 'Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study', Archives of Gynecology and Obstetrics, vol. 308, no. 1, pp. 117-125. https://doi.org/10.1007/s00404-022-06712-z

TY - JOUR

T1 - Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study

AU - Kosian, Philipp

AU - Hellmund, Astrid

AU - Geipel, Annegret

AU - Bald, Rainer

AU - Geist, Otilia Maria

AU - Böckenhoff, Paul

AU - Jimenez-Cruz, Jorge

AU - Deja, Maria

AU - Strizek, Brigitte

AU - Berg, Christoph

AU - Gembruch, Ulrich

PY - 2023/7

Y1 - 2023/7

N2 - Purpose: Evaluating procedure-related complications and perinatal outcomes after intrauterine transfusion (IUT) before or after 20+0 weeks of gestation in fetuses with severe anemia due to intrauterine human parvovirus B19 infection. Methods: A retrospective study investigating fetuses requiring IUT for fetal Parvo B19 infection in two tertiary referral centers between December 2002 and December 2021. Procedure-related complications, intrauterine fetal death (IUFD), and perinatal outcome were correlated to gestational age (GA) at first IUT, the presence of hydrops and fetal blood sampling results. Results: A total of 186 IUTs were performed in 103 fetuses. The median GA at first IUT was 19+3 (13+0–31+4) weeks of gestation. IUFD occurred in 16/103 fetuses (15.5%). Overall survival was 84.5% (87/103). Hydrops (p = 0.001), lower mean hemoglobin at first IUT (p = 0.001) and low platelets (p = 0.002) were strongly associated with IUFD. There was no difference observed in fetuses transfused before or after 20+0 weeks of gestation. Conclusion: IUT is a successful treatment option in fetuses affected by severe anemia due to parvovirus B19 infection in specialized centers. In experienced hands, IUT before 20 weeks is not related to worse perinatal outcome.

AB - Purpose: Evaluating procedure-related complications and perinatal outcomes after intrauterine transfusion (IUT) before or after 20+0 weeks of gestation in fetuses with severe anemia due to intrauterine human parvovirus B19 infection. Methods: A retrospective study investigating fetuses requiring IUT for fetal Parvo B19 infection in two tertiary referral centers between December 2002 and December 2021. Procedure-related complications, intrauterine fetal death (IUFD), and perinatal outcome were correlated to gestational age (GA) at first IUT, the presence of hydrops and fetal blood sampling results. Results: A total of 186 IUTs were performed in 103 fetuses. The median GA at first IUT was 19+3 (13+0–31+4) weeks of gestation. IUFD occurred in 16/103 fetuses (15.5%). Overall survival was 84.5% (87/103). Hydrops (p = 0.001), lower mean hemoglobin at first IUT (p = 0.001) and low platelets (p = 0.002) were strongly associated with IUFD. There was no difference observed in fetuses transfused before or after 20+0 weeks of gestation. Conclusion: IUT is a successful treatment option in fetuses affected by severe anemia due to parvovirus B19 infection in specialized centers. In experienced hands, IUT before 20 weeks is not related to worse perinatal outcome.

UR - http://www.scopus.com/inward/record.url?scp=85135288482&partnerID=8YFLogxK

U2 - 10.1007/s00404-022-06712-z

DO - 10.1007/s00404-022-06712-z

M3 - Journal articles

C2 - 35916962

AN - SCOPUS:85135288482

SN - 0932-0067

VL - 308

SP - 117

EP - 125

JO - Archives of Gynecology and Obstetrics

JF - Archives of Gynecology and Obstetrics

IS - 1

ER -

Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study

Abstract

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