Intratumoraler pO2, S-phase-Anteil und p53-Status bei Zervixkarzinomen

Translated title of the contribution: Intratumoral pO2, S-phase fraction and p53-status in cervical cancers

G. Hänsgen*, I. Hintner, V. Krause, W. Wohlrab, J. Dunst

*Corresponding author for this work
9 Citations (Scopus)


Purpose: Investigation whether tumor tissue oxygenation is influenced by proliferation or p53-status in cervical cancers. Material and Methods: From April 1995 through December 1996, 28 patients with locally advanced cervical cancers (age 36 to 78 years; FIGO stages: 10 patients IIB, 16 patients IIIB, 2 patients IVA) underwent intratumoral measurement of pO2 prior to definitive radiotherapy. The histological specimens were examined for grading and quantitative immunohistological expression of the MIB-antigen and p53- protein. Proliferation was estimated by measuring the S-phase fraction with flow cytometry. Results: The median pO2-values showed a broad variation from 2.2 through 60.4 mm Hg, median 19.7 mm Hg. The S-phase fraction varied from 4.2 through 34.2% (median 11.6%), MIB-positive cells from 20 through 100% (median 74%), and immunohistologically p53-positive cells from 0 through 95% (median 2%). The patients were divided in 2 groups according to the pretreatment pO2. Tumors with a pO2 above the median had a lower S-phase fraction than tumors with a pO2 below the median, 10.4 ± 3.8% versus 16.3 ± 5.5%, p < 0.02. MIB and p53 were not different in both groups (MIB: 68.1 ± 27.7% versus 75.0 ± 18.4%, p = 0.1; p53: 26.4 ± 38.5% versus 18.1 ± 19.8%, n. s.). Grade of differentiation and FIGO stage had no impact on pO2 Conclusion: Locally advanced cervical cancers with a poor oxygenation have a higher proliferative activity. Tumor proliferation may play a causative role for the development of hypoxia as suspected from radiobiological theories.

Translated title of the contributionIntratumoral pO2, S-phase fraction and p53-status in cervical cancers
Original languageGerman
JournalStrahlentherapie und Onkologie
Issue number7
Pages (from-to)385-387
Number of pages3
Publication statusPublished - 1997


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