Intrathecal thyroid autoantibody synthesis in a subgroup of patients with schizophreniform syndromes

Dominique Endres; Rick Dersch; Benedikt Hochstuhl; Bernd Fiebich; Tilman Hottenrott; Evgeniy Perlov; Simon Maier; Benjamin Berger; Annette Baumgartner; Nils Venhoff; Oliver Stich; Ludger Tebartz van Elst

doi:10.1176/appi.neuropsych.16110296

Intrathecal thyroid autoantibody synthesis in a subgroup of patients with schizophreniform syndromes

Dominique Endres^*, Rick Dersch, Benedikt Hochstuhl, Bernd Fiebich, Tilman Hottenrott, Evgeniy Perlov, Simon Maier, Benjamin Berger, Annette Baumgartner, Nils Venhoff, Oliver Stich, Ludger Tebartz van Elst

^*Corresponding author for this work

Institute of Health Sciences

University of Freiburg

17 Citations (Scopus)

Abstract

Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto’s encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Increased antibody indices (AIs) for antithyroid peroxidase or antithyroglobulin autoantibodies in 13 schizophreniform patients were found. AIs were increased in 68% of the seropositive patients. These findings support the hypothesis that autoimmune processes may contribute to the pathophysiology in these patients.

Original language	English
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	29
Issue number	4
Pages (from-to)	365-374
Number of pages	10
ISSN	0895-0172
DOIs	https://doi.org/10.1176/appi.neuropsych.16110296
Publication status	Published - 01.09.2017

Funding

Supported by the Department for Psychiatry and Psychotherapy of the University Medical Center Freiburg. BF has received grant and research support from Bayer Vital GmbH. TH has received travel grants from Bayer Vital GmbH and Novartis. BB has received travel grants from Bayer Vital GmbH, Ipsen Pharma GmbH, and Genzyme. AB has received consulting and lecture fees, as well as grant and research support, from Bayer Vital GmbH, Biogen Idec, Merck Serono, Novartis, Sanofi-Aventis, and Teva. NV has served on advisory boards of, has participated in lectures for, and/or received research or travel grants from AbbVie, GSK, Janssen-Cilag, Medac, Novartis, and Roche. OS has received consulting and lecture fees and grant and research support from Bayer Vital GmbH, Biogen Idec, Genzyme, Merck Serono, Novartis, Sanofi-Aventis, and Teva. LTvE has served on advisory boards of, has participated in lectures for, and/or received travel grants from Cyberonics, Eli Lilly, GlaxoSmithKline, Janssen, Janssen-Cilag, Novartis, Servier, Shire, and UCB. All other authors report no financial relationships with commercial interests.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Health Sciences

DFG Research Classification Scheme

2.22-22 Clinical Immunology and Allergology
2.23-09 Biological Psychiatry

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Endres, D., Dersch, R., Hochstuhl, B., Fiebich, B., Hottenrott, T., Perlov, E., Maier, S., Berger, B., Baumgartner, A., Venhoff, N., Stich, O., & van Elst, L. T. (2017). Intrathecal thyroid autoantibody synthesis in a subgroup of patients with schizophreniform syndromes. Journal of Neuropsychiatry and Clinical Neurosciences, 29(4), 365-374. https://doi.org/10.1176/appi.neuropsych.16110296

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abstract = "Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto{\textquoteright}s encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Increased antibody indices (AIs) for antithyroid peroxidase or antithyroglobulin autoantibodies in 13 schizophreniform patients were found. AIs were increased in 68\% of the seropositive patients. These findings support the hypothesis that autoimmune processes may contribute to the pathophysiology in these patients.",

author = "Dominique Endres and Rick Dersch and Benedikt Hochstuhl and Bernd Fiebich and Tilman Hottenrott and Evgeniy Perlov and Simon Maier and Benjamin Berger and Annette Baumgartner and Nils Venhoff and Oliver Stich and \{van Elst\}, \{Ludger Tebartz\}",

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Endres, D, Dersch, R, Hochstuhl, B, Fiebich, B, Hottenrott, T, Perlov, E, Maier, S, Berger, B, Baumgartner, A, Venhoff, N, Stich, O & van Elst, LT 2017, 'Intrathecal thyroid autoantibody synthesis in a subgroup of patients with schizophreniform syndromes', Journal of Neuropsychiatry and Clinical Neurosciences, vol. 29, no. 4, pp. 365-374. https://doi.org/10.1176/appi.neuropsych.16110296

TY - JOUR

T1 - Intrathecal thyroid autoantibody synthesis in a subgroup of patients with schizophreniform syndromes

AU - Endres, Dominique

AU - Dersch, Rick

AU - Hochstuhl, Benedikt

AU - Fiebich, Bernd

AU - Hottenrott, Tilman

AU - Perlov, Evgeniy

AU - Maier, Simon

AU - Berger, Benjamin

AU - Baumgartner, Annette

AU - Venhoff, Nils

AU - Stich, Oliver

AU - van Elst, Ludger Tebartz

PY - 2017/9/1

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N2 - Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto’s encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Increased antibody indices (AIs) for antithyroid peroxidase or antithyroglobulin autoantibodies in 13 schizophreniform patients were found. AIs were increased in 68% of the seropositive patients. These findings support the hypothesis that autoimmune processes may contribute to the pathophysiology in these patients.

AB - Schizophreniform syndromes in combination with autoimmune thyroiditis and increased serum thyroid antibodies lead healthcare practitioners to consider a diagnosis of Hashimoto’s encephalopathy. To detect specific biomarkers, the authors analyzed whether intrathecal antithyroid antibody synthesis occurred in a subgroup of schizophreniform patients. In doing so, the authors analyzed thyroid antibodies in paired cerebrospinal fluid and serum samples from 100 schizophreniform patients. Increased antibody indices (AIs) for antithyroid peroxidase or antithyroglobulin autoantibodies in 13 schizophreniform patients were found. AIs were increased in 68% of the seropositive patients. These findings support the hypothesis that autoimmune processes may contribute to the pathophysiology in these patients.

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U2 - 10.1176/appi.neuropsych.16110296

DO - 10.1176/appi.neuropsych.16110296

M3 - Journal articles

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SN - 0895-0172

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JO - Journal of Neuropsychiatry and Clinical Neurosciences

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ER -

Intrathecal thyroid autoantibody synthesis in a subgroup of patients with schizophreniform syndromes

Abstract

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