Interventional radiotherapy (brachytherapy) for squamous cell carcinoma of the nasal vestibule: a multidisciplinary systematic review

Luca Tagliaferri, Bruno Fionda, Francesco Bussu*, Claudio Parrilla, Valentina Lancellotta, Francesco Deodato, Silvia Cammelli, Luca Boldrini, Maria Aantonietta Gambacorta, Alessio Giuseppe Morganti, Vincenzo Valentini, Gaetano Paludetti, Ketty Peris, György Kovacs

*Corresponding author for this work
4 Citations (Scopus)


Background: Surgery is the first-line therapy for treatment of cutaneous squamous cell carcinoma (cSCC), and interventional radiotherapy is recommended when surgery is not feasible, contraindicated, or refused by the patient. Objectives: To provide a multidisciplinary systematic review of the role of interventional radiotherapy for the treatment of cSCC of the nasal vestibule. Materials and Methods: A systematic search was performed; primary outcomes were tumour local control and overall survival. Acute toxicity, late toxicity, and functional cosmetic results, regardless of the scoring systems used, were secondary outcomes. Results: After full-text reviewof the 92 papers initially identified, we included only 10 papers in the review; no randomized controlled trials or prospective studies were identified. Five studies reported five-year local control, with rates ranging between 69% and 97%. A high level of heterogeneity was observed regarding the methods used to assess treatment-related toxicity. Conclusion: Interventional radiotherapy may be considered for lesions specifically arising from the area of the nasal vestibule. A multidisciplinary approach might help to select cases that are potential candidates for conservative treatment according to the tumour and the patient’s features.

Original languageEnglish
JournalEuropean Journal of Dermatology
Issue number4
Pages (from-to)417-421
Number of pages5
Publication statusPublished - 01.07.2019


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