Sensing of environmental parameters is critically important for cells of metazoan organisms. Members of the superfamily of bHLH‐PAS transcription factors, involved in oxygen sensing and circadian rhythm generation, are important players in such molecular pathways. The interplay between both networks includes a so far unknown factor, connecting PER2 (circadian clocks) to hypoxia sensing (HIF‐1 α) to result in a more adapted state of homeostasis at the right time.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)