International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance

Daniel Rudolf; Nikolay Michaylov; Mark Van Der Linden; Ludwig Hoy; Keith P. Klugman; Tobias Welte; Mathias W. Pletz

doi:10.1128/AAC.00250-11

International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance

Daniel Rudolf, Nikolay Michaylov, Mark Van Der Linden, Ludwig Hoy, Keith P. Klugman, Tobias Welte, Mathias W. Pletz^*

^*Corresponding author for this work

Clinic of Internal Medicine III - Pulmonology

7 Citations (Scopus)

Abstract

A few international pneumococcal clones dominate the population of antibiotic-resistant pneumococci. Despite the scientific paradigm that a loss in fitness is the price for acquisition of resistance, these clones spread successfully. One hundred fifty-four isolates from adult patients with community-acquired pneumonia (CAP) were analyzed. Thirty percent showed a close relationship to international clones and had fitness equal to or exceeding that of other strains (P = 0.015); these factors may result in the endurance of these strains despite a reduction of antibiotic usage.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	10
Pages (from-to)	4915-4917
Number of pages	3
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.00250-11
Publication status	Published - 01.10.2011

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AU - Klugman, Keith P.

AU - Welte, Tobias

AU - Pletz, Mathias W.

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International pneumococcal clones match or exceed the fitness of other strains despite the accumulation of antibiotic resistance

Abstract

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