TY - JOUR
T1 - Interleukin-6-174-genotype, sepsis and cerebral injury in very low birth weight infants
AU - Göpel, W.
AU - Härtel, C.
AU - Ahrens, P.
AU - König, I.
AU - Kattner, E.
AU - Kuhls, E.
AU - Küster, H.
AU - Möller, J.
AU - Müller, D.
AU - Roth, B.
AU - Segerer, H.
AU - Wieg, C.
AU - Herting, E.
N1 - Funding Information:
The authors thank Anja Sewe and Sabine Ziesenitz for excellent laboratory assistance, Birgit Roenspiess and Anne Hoegemann for skillful data collection, all doctors and nurses of the participating hospitals, and especially all infants and their parents for their support. This work was supported by the Deutsche Forschungsge-meinschaft, Grant-no. Go955/1-3.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2006/1
Y1 - 2006/1
N2 - We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8%, IL-6-174GC (n = 605) 9% and IL-6-174CC (n = 167) 12% (P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers (n=157), 26% of IL-6-174GC-carriers (n = 193) and 27% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.
AB - We investigated the association between the interleukin 6 (IL-6)-174-genotype and unfavorable outcomes in preterm infants since it has been reported that the IL-6-174GG-genotype is associated with increased susceptibility to sepsis, and the IL-6-174CC-genotype is more common in preterm infants with severe intraventricular hemorrhage (IVH). We studied 1206 preterm infants with a birth weight below 1500 g. In contrast to previously published data, the frequency of IVH grade IV, periventricular leukomalacia, ventricular-peritoneal-shunting or death was not different between infants with different IL-6-genotypes: IL-6-174GG (n = 430) 8%, IL-6-174GC (n = 605) 9% and IL-6-174CC (n = 167) 12% (P = 0.2 for IL-6-174CC vs GG+GC). Furthermore, we were not able to confirm previously reported association between sepsis and the IL-6-174GG-genotype. Blood-culture-proven sepsis occurred in 19% of IL-6-174GG-carriers (n=157), 26% of IL-6-174GC-carriers (n = 193) and 27% of infants carrying the IL-6-174CC-genotype (n = 67). We were not able to confirm previously reported associations between sepsis, cerebral injury and the IL-6-174-genotype in VLBW-infants.
UR - http://www.scopus.com/inward/record.url?scp=33645137794&partnerID=8YFLogxK
U2 - 10.1038/sj.gene.6364264
DO - 10.1038/sj.gene.6364264
M3 - Journal articles
C2 - 16208404
AN - SCOPUS:33645137794
SN - 1466-4879
VL - 7
SP - 65
EP - 68
JO - Genes and Immunity
JF - Genes and Immunity
IS - 1
ER -
