TY - JOUR
T1 - Interleukin-1 beta, interleukin-6 and TGF-beta in follicular tissue of impacted third molars
AU - Mesgarzadeh, Ali Hossein
AU - Abolfathi, Ali Akbar
AU - Dastgiri, Saeed
AU - Shaaker, Maghsod
AU - Vatankhah, Amir Mansour
AU - Solehakahnamoiee, Shiva
AU - Darabi, Masoud
PY - 2011/6
Y1 - 2011/6
N2 - The clinical evaluation and management of impacted third molars remain challenging. The aim of the present study was to investigate possible associations between follicular tissue cytokines and radiographic manifestations of impacted third molar. The population included 72 patients who underwent surgical extraction of impacted third molars. All these patients underwent a preliminary panoramic radiograph. Levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and transforming growth factor beta (TGF-β) in tissue extracts were determined using ELISA. There were no significant differences between bony and tissue impaction as regards IL-1β, IL-6 and TGF-β levels. Moreover, the same results were obtained as far as the amount of pericoronal space and the presence or absence of a history of pericoronitis are concerned. These results suggest that radiographic findings or a history of pericoronitis are not associated with levels of expression of pro-inflammatory cytokines in patients undergoing surgical removal of impacted third molars.However, further studies are needed to address the possibility of variability during disease progression.
AB - The clinical evaluation and management of impacted third molars remain challenging. The aim of the present study was to investigate possible associations between follicular tissue cytokines and radiographic manifestations of impacted third molar. The population included 72 patients who underwent surgical extraction of impacted third molars. All these patients underwent a preliminary panoramic radiograph. Levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and transforming growth factor beta (TGF-β) in tissue extracts were determined using ELISA. There were no significant differences between bony and tissue impaction as regards IL-1β, IL-6 and TGF-β levels. Moreover, the same results were obtained as far as the amount of pericoronal space and the presence or absence of a history of pericoronitis are concerned. These results suggest that radiographic findings or a history of pericoronitis are not associated with levels of expression of pro-inflammatory cytokines in patients undergoing surgical removal of impacted third molars.However, further studies are needed to address the possibility of variability during disease progression.
UR - http://www.scopus.com/inward/record.url?scp=79960991900&partnerID=8YFLogxK
U2 - 10.1684/ecn.2011.0286
DO - 10.1684/ecn.2011.0286
M3 - Journal articles
C2 - 21727060
AN - SCOPUS:79960991900
SN - 1148-5493
VL - 22
SP - 103
EP - 106
JO - European Cytokine Network
JF - European Cytokine Network
IS - 2
ER -
