Interferometric optical online dosimetry for Selective Retina Treatment (SRT)

Hardo Stoehr; Lars Ptaszynski; Andreas Fritz; Ralf Brinkmann

doi:10.1117/12.708521

Interferometric optical online dosimetry for Selective Retina Treatment (SRT)

Hardo Stoehr^*, Lars Ptaszynski, Andreas Fritz, Ralf Brinkmann

^*Corresponding author for this work

Institute of Biomedical Optics

Abstract

In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.

Original language	English
Title of host publication	Ophthalmic Technologies XVII
Editors	Bruce E. Stuck, Michael Belkin , Fabrice Manns, Per G. Söderberg, Arthur Ho
Number of pages	7
Volume	6426
Publisher	SPIE
Publication date	05.03.2007
Article number	642619
ISBN (Print)	978-081946539-9
DOIs	https://doi.org/10.1117/12.708521
Publication status	Published - 05.03.2007
Event	Ophthalmic Technologies XVII - San Jose, United States Duration: 20.01.2007 → 23.01.2007 Conference number: 70151

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Academic Focus: Biomedical Engineering

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Stoehr, H., Ptaszynski, L., Fritz, A., & Brinkmann, R. (2007). Interferometric optical online dosimetry for Selective Retina Treatment (SRT). In B. E. Stuck, M. Belkin , F. Manns, P. G. Söderberg, & A. Ho (Eds.), Ophthalmic Technologies XVII (Vol. 6426). Article 642619 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6426). SPIE. https://doi.org/10.1117/12.708521

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abstract = "In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.",

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Stoehr, H, Ptaszynski, L, Fritz, A & Brinkmann, R 2007, Interferometric optical online dosimetry for Selective Retina Treatment (SRT). in B E. Stuck, M Belkin , F Manns, P G. Söderberg & A Ho (eds), Ophthalmic Technologies XVII. vol. 6426, 642619, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6426, SPIE, Ophthalmic Technologies XVII , San Jose, California, United States, 20.01.07. https://doi.org/10.1117/12.708521

Interferometric optical online dosimetry for Selective Retina Treatment (SRT). / Stoehr, Hardo; Ptaszynski, Lars; Fritz, Andreas et al.
Ophthalmic Technologies XVII. ed. / Bruce E. Stuck; Michael Belkin ; Fabrice Manns; Per G. Söderberg; Arthur Ho. Vol. 6426 SPIE, 2007. 642619 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6426).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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T1 - Interferometric optical online dosimetry for Selective Retina Treatment (SRT)

AU - Stoehr, Hardo

AU - Ptaszynski, Lars

AU - Fritz, Andreas

AU - Brinkmann, Ralf

N1 - Conference code: 70151

PY - 2007/3/5

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N2 - In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.

AB - In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.

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M3 - Conference contribution

SN - 978-081946539-9

VL - 6426

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Ophthalmic Technologies XVII

A2 - E. Stuck, Bruce

A2 - Belkin , Michael

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A2 - G. Söderberg, Per

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Y2 - 20 January 2007 through 23 January 2007

ER -

Interferometric optical online dosimetry for Selective Retina Treatment (SRT)

Abstract

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