Interferometric detection of laser induced microbubbles in the retinal pigment epithelium

Jörg Neumann; Ralf Brinkmann

doi:10.1117/12.446505

Interferometric detection of laser induced microbubbles in the retinal pigment epithelium

Jörg Neumann^*, Ralf Brinkmann

^*Corresponding author for this work

Institute of Biomedical Optics

4 Citations (Scopus)

Abstract

We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527 nm, 350 ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.

Original language	English
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4433
Pages (from-to)	81-86
Number of pages	6
ISSN	0277-786X
DOIs	https://doi.org/10.1117/12.446505
Publication status	Published - 26.10.2001
Event	Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy 2001 - Munich, Germany Duration: 18.06.2001 → 21.06.2001 Conference number: 59925

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Academic Focus: Biomedical Engineering

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abstract = "We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527 nm, 350 ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.",

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N2 - We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527 nm, 350 ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.

AB - We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527 nm, 350 ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.

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M3 - Conference Articles in Journals

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JO - Proceedings of SPIE - The International Society for Optical Engineering

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Interferometric detection of laser induced microbubbles in the retinal pigment epithelium

Abstract

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