Interferometric detection of laser induced microbubbles in the retinal pigment epithelium

Jörg Neumann*, Ralf Brinkmann

*Corresponding author for this work


We developed an interferometric technique in order to detect microbubble formation within porcine retinal pigment epithelial (RPE) cells ex vivo after short pulsed laser exposure (527 nm, 350 ns). The irradiated surface of the RPE tissue samples was monitored by a Michelson interferometer. The obtained interferometric transients revealed bubble dynamics and were compared to optoacoustic transients recorded simultaneously. This interferometric technique might be useful for in vivo dosimetry during selective RPE-treatment.

Original languageEnglish
JournalProceedings of SPIE - The International Society for Optical Engineering
Pages (from-to)81-86
Number of pages6
Publication statusPublished - 26.10.2001
EventLaser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy 2001
- Munich, Germany
Duration: 18.06.200121.06.2001
Conference number: 59925

Research Areas and Centers

  • Academic Focus: Biomedical Engineering


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