Interactions Between the Complement System and Fcγ Receptors

Margaret A. Lindorfer*, Jörg Köhl, Ronald P. Taylor

*Corresponding author for this work
11 Citations (Scopus)


The key roles of the complement cascade and cellular Fcγ receptors in the innate and adaptive immune system are well documented. Recognition of soluble or cell-bound IgG-containing immune complexes by either of these two respective effector systems leads to a complex series of separate and non-overlapping inflammatory reactions and cytotoxic processes, each of which serves to remove or destroy opsonized microorganisms or targeted tumor cells. Alternatively, in autoimmune diseases these reactions mediate severe pathologies which are manifested in local or systemic inflammation as well as in tissue injury. For some time, it appeared that these two effector systems functioned independently and did not communicate; however, increasing evidence reveals synergy and feedback control between these two systems. Indeed, danger signals can alert one system leading to cross-communication and cooperation with the other to efficiently eliminate the threat. On the other hand, undesired and deleterious inflammation can be controlled by FcγR-mediated suppression of complement.

Original languageEnglish
Title of host publicationAntibody Fc: Linking Adaptive and Innate Immunity
Number of pages26
PublisherElsevier Inc.
Publication date09.2013
ISBN (Print)9780123948021
Publication statusPublished - 09.2013

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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