Interactions between endocrine and circadian systems

Anthony H. Tsang, Johanna L. Barclay, Henrik Oster*

*Corresponding author for this work
33 Citations (Scopus)


In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock-hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

Original languageEnglish
JournalJournal of Molecular Endocrinology
Issue number1
Pages (from-to)R1–R16
Number of pages16
Publication statusPublished - 30.08.2013

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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