Intensity Gradient Based Registration and Fusion of Multi-Modal Images

Eldad Haber*, Jan Modersitzki

*Corresponding author for this work
79 Citations (Scopus)


Objectives: A particular problem in image registration arises for multi-modal images taken from different imaging devices and/or modalities. Starting in 1995, mutual information has shown to be a very successful distance measure for multi-modal image registration. Therefore, mutual information is considered to be the state-of-the-art approach to multi-modal image registration. However, mutual information has also a number of well-known drawbacks. Its main disadvantage is that it is known to be highly non-convex and has typically many local maxima. Methods: This observation motivates us to seek a different image similarity measure which is better suited for optimization but as well capable to handle multimodal images. Results: In this work, we investigate an alternative distance measure which is based on normalized gradients. Conclusions: As we show, the alternative approach is deterministic, much simpler, easier to interpret, fast and straightforward to implement, faster to compute, and also much more suitable to numerical optimization.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention – MICCAI 2006
Number of pages8
Place of PublicationBerlin, Heidelberg
PublisherSpringer Verlag
Publication date30.05.2007
ISBN (Print)978-3-540-44727-6
ISBN (Electronic)978-3-540-44728-3
Publication statusPublished - 30.05.2007
EventInternational Conference on Medical Image Computing and Computer-Assisted Intervention 2006 - Copenhagen, Denmark
Duration: 01.10.200606.10.2006


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