Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia

Marcus Meinzer; Siawoosh Mohammadi; Harald Kugel; Hagen Schiffbauer; Agnes Flöel; Johannes Albers; Kira Kramer; Ricarda Menke; Annette Baumgärtner; Stefan Knecht; Caterina Breitenstein; Michael Deppe

doi:10.1016/j.neuroimage.2010.06.004

Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia

Marcus Meinzer^*, Siawoosh Mohammadi, Harald Kugel, Hagen Schiffbauer, Agnes Flöel, Johannes Albers, Kira Kramer, Ricarda Menke, Annette Baumgärtner, Stefan Knecht, Caterina Breitenstein, Michael Deppe

^*Corresponding author for this work

Institute of Health Sciences

80 Citations (Scopus)

Abstract

Aphasia after middle cerebral artery (MCA) stroke shows highly variable degrees of recovery. One possible explanation may be offered by the variability of the occlusion location. Branches from the proximal portion of the MCA often supply the mesial temporal lobe including parts of the hippocampus, a structure known to be involved in language learning. Therefore, we assessed whether language recovery in chronic aphasia is dependent on the proximity of the MCA infarct and correlated with the integrity of the hippocampus and its surrounding white matter. Language reacquisition capability was determined after 2. weeks of intensive language therapy and 8. months after treatment in ten chronic aphasia patients. Proximity of MCA occlusion relative to the internal carotid artery was determined by magnetic resonance imaging (MRI) based on the most proximal anatomical region infarcted. Structural damage to the hippocampus was assessed by MRI-based volumetry, regional microstructural integrity of hippocampus adjacent white matter by fractional anisotropy. Language learning success for trained materials was correlated with the proximity of MCA occlusion, microstructural integrity of the left hippocampus and its surrounding white matter, but not with lesion size, overall microstructural brain integrity and a control region outside of the MCA territory. No correlations were found for untrained language materials, underlining the specificity of our results for training-induced recovery. Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures.

Original language	English
Journal	NeuroImage
Volume	53
Issue number	1
Pages (from-to)	283-290
Number of pages	8
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2010.06.004
Publication status	Published - 10.2010

Funding

This work was supported by the Bundesministerium für Bildung und Forschung ( 01GW0520, 0101-31 P6427 ); the Volkswagen Foundation ( I/80708 ); the European Commission ( MRTN-CT-2004-512141 ); the Interdisciplinary Center for Clinical Research of the University of Münster ( Floe 3-004-008 ); the Stiftung Neuromedizin Münster; and the German Foundation for Science (SFB/TR3 A08 and A10, ME 3161/2-1, Fl 379-8/1). We thank Dr. K. Heilman for helpful comments on a previous version of this manuscript and Dr. S. Harnish for editorial assistance.

Research Areas and Centers

Health Sciences

DFG Research Classification Scheme

2.23-07 Clinical Neurology, Neurosurgery and Neuroradiology
2.23-08 Human Cognitive and Systems Neuroscience
2.23-05 Experimental Models for the Understanding of Nervous System Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuroimage.2010.06.004

Cite this

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title = "Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia",

abstract = "Aphasia after middle cerebral artery (MCA) stroke shows highly variable degrees of recovery. One possible explanation may be offered by the variability of the occlusion location. Branches from the proximal portion of the MCA often supply the mesial temporal lobe including parts of the hippocampus, a structure known to be involved in language learning. Therefore, we assessed whether language recovery in chronic aphasia is dependent on the proximity of the MCA infarct and correlated with the integrity of the hippocampus and its surrounding white matter. Language reacquisition capability was determined after 2. weeks of intensive language therapy and 8. months after treatment in ten chronic aphasia patients. Proximity of MCA occlusion relative to the internal carotid artery was determined by magnetic resonance imaging (MRI) based on the most proximal anatomical region infarcted. Structural damage to the hippocampus was assessed by MRI-based volumetry, regional microstructural integrity of hippocampus adjacent white matter by fractional anisotropy. Language learning success for trained materials was correlated with the proximity of MCA occlusion, microstructural integrity of the left hippocampus and its surrounding white matter, but not with lesion size, overall microstructural brain integrity and a control region outside of the MCA territory. No correlations were found for untrained language materials, underlining the specificity of our results for training-induced recovery. Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures.",

author = "Marcus Meinzer and Siawoosh Mohammadi and Harald Kugel and Hagen Schiffbauer and Agnes Fl{\"o}el and Johannes Albers and Kira Kramer and Ricarda Menke and Annette Baumg{\"a}rtner and Stefan Knecht and Caterina Breitenstein and Michael Deppe",

note = "Funding Information: This work was supported by the Bundesministerium f{\"u}r Bildung und Forschung ( 01GW0520, 0101-31 P6427 ); the Volkswagen Foundation ( I/80708 ); the European Commission ( MRTN-CT-2004-512141 ); the Interdisciplinary Center for Clinical Research of the University of M{\"u}nster ( Floe 3-004-008 ); the Stiftung Neuromedizin M{\"u}nster; and the German Foundation for Science (SFB/TR3 A08 and A10, ME 3161/2-1, Fl 379-8/1). We thank Dr. K. Heilman for helpful comments on a previous version of this manuscript and Dr. S. Harnish for editorial assistance. ",

year = "2010",

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doi = "10.1016/j.neuroimage.2010.06.004",

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pages = "283--290",

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T1 - Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia

AU - Meinzer, Marcus

AU - Mohammadi, Siawoosh

AU - Kugel, Harald

AU - Schiffbauer, Hagen

AU - Flöel, Agnes

AU - Albers, Johannes

AU - Kramer, Kira

AU - Menke, Ricarda

AU - Baumgärtner, Annette

AU - Knecht, Stefan

AU - Breitenstein, Caterina

AU - Deppe, Michael

N1 - Funding Information: This work was supported by the Bundesministerium für Bildung und Forschung ( 01GW0520, 0101-31 P6427 ); the Volkswagen Foundation ( I/80708 ); the European Commission ( MRTN-CT-2004-512141 ); the Interdisciplinary Center for Clinical Research of the University of Münster ( Floe 3-004-008 ); the Stiftung Neuromedizin Münster; and the German Foundation for Science (SFB/TR3 A08 and A10, ME 3161/2-1, Fl 379-8/1). We thank Dr. K. Heilman for helpful comments on a previous version of this manuscript and Dr. S. Harnish for editorial assistance.

PY - 2010/10

Y1 - 2010/10

N2 - Aphasia after middle cerebral artery (MCA) stroke shows highly variable degrees of recovery. One possible explanation may be offered by the variability of the occlusion location. Branches from the proximal portion of the MCA often supply the mesial temporal lobe including parts of the hippocampus, a structure known to be involved in language learning. Therefore, we assessed whether language recovery in chronic aphasia is dependent on the proximity of the MCA infarct and correlated with the integrity of the hippocampus and its surrounding white matter. Language reacquisition capability was determined after 2. weeks of intensive language therapy and 8. months after treatment in ten chronic aphasia patients. Proximity of MCA occlusion relative to the internal carotid artery was determined by magnetic resonance imaging (MRI) based on the most proximal anatomical region infarcted. Structural damage to the hippocampus was assessed by MRI-based volumetry, regional microstructural integrity of hippocampus adjacent white matter by fractional anisotropy. Language learning success for trained materials was correlated with the proximity of MCA occlusion, microstructural integrity of the left hippocampus and its surrounding white matter, but not with lesion size, overall microstructural brain integrity and a control region outside of the MCA territory. No correlations were found for untrained language materials, underlining the specificity of our results for training-induced recovery. Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures.

AB - Aphasia after middle cerebral artery (MCA) stroke shows highly variable degrees of recovery. One possible explanation may be offered by the variability of the occlusion location. Branches from the proximal portion of the MCA often supply the mesial temporal lobe including parts of the hippocampus, a structure known to be involved in language learning. Therefore, we assessed whether language recovery in chronic aphasia is dependent on the proximity of the MCA infarct and correlated with the integrity of the hippocampus and its surrounding white matter. Language reacquisition capability was determined after 2. weeks of intensive language therapy and 8. months after treatment in ten chronic aphasia patients. Proximity of MCA occlusion relative to the internal carotid artery was determined by magnetic resonance imaging (MRI) based on the most proximal anatomical region infarcted. Structural damage to the hippocampus was assessed by MRI-based volumetry, regional microstructural integrity of hippocampus adjacent white matter by fractional anisotropy. Language learning success for trained materials was correlated with the proximity of MCA occlusion, microstructural integrity of the left hippocampus and its surrounding white matter, but not with lesion size, overall microstructural brain integrity and a control region outside of the MCA territory. No correlations were found for untrained language materials, underlining the specificity of our results for training-induced recovery. Our results suggest that intensive language therapy success in chronic aphasia after MCA stroke is critically dependent on damage to the hippocampus and its surrounding structures.

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U2 - 10.1016/j.neuroimage.2010.06.004

DO - 10.1016/j.neuroimage.2010.06.004

M3 - Journal articles

C2 - 20541018

AN - SCOPUS:77955304894

SN - 1053-8119

VL - 53

SP - 283

EP - 290

JO - NeuroImage

JF - NeuroImage

IS - 1

ER -

Integrity of the hippocampus and surrounding white matter is correlated with language training success in aphasia

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

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