Initial MPS Response of Adsorptively-Coated Fluorescent Iron Oxide Nanoparticles

Jabadurai Jayapaul, Daniel Truhn, Fabian Kiessling, Kerstin Lüdtke-Buzug, ThorstenM. Buzug


The search for optimal nanoparticlesfor magnetic particle imaging (MPI) has been receiving much attention. Currently, Resovist® an iron oxide nanoparticle-based MR contrast agent is considered as the gold standard for MPS and MPI measurements. In this paper, we evaluate the initial MPS response of iron oxide-based nanoparticle systems with variation in core size and coating. In this context, we synthesized iron oxide nanoparticles with different core sizes (5 and 10 nm) by employing co-preciptiation method. Further, these iron cores were adsorptivelycoated with endogenous fluorophores (flavin analogues: FMN, FAD) to increase their stability and to enhance MR contrast. We have performed initial experiments on these particles in a magnetic particle spectrometer. Their spectrum of higher harmonics was obtained and found to fall off more rapidly than Resovist®. No difference in magnetic behavior was seen between particles with different coatings.
Original languageEnglish
Title of host publicationMagnetic Particle Imaging
EditorsThorsten M. Buzug, Jörn Borgert
Number of pages6
PublisherSpringer Berlin Heidelberg
Publication date2012
ISBN (Print)978-3-642-24132-1
ISBN (Electronic)978-3-642-24133-8
Publication statusPublished - 2012
Event2th International Workshop on Magnetic Particle Imaging (IWMPI 2012) - Lübeck, Germany
Duration: 15.03.201216.03.2012


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