Initial amyopathische Dermatomyositis mit Lungenbeteiligung und Anti-MDA5-Antikörpern

Translated title of the contribution: Initially Amyopathic Dermatomyositis with Lung Involvement and anti-MDA5 Antibodies

N. Schumacher*, P. Rudolphi, D. Zillikens

*Corresponding author for this work


Dermatomyositis is a chronic inflammatory disorder with characteristic skin findings and a variable degree of muscle involvement. Some patients present with typical cutaneous manifestations but have subclinical (hypomyopathic) or absent (amyopathic) muscle disease. In these cases the diagnosis can be delayed, which might have a negative effect on the patient outcome. Determination of myositis-specific autoantibodies may help in this clinical situation. Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis is frequently associated with rapidly progressive interstitial lung disease. We report a case of a 56-year old woman with initially no dermatomyositis-typical skin or laboratory findings, where the correlation of clinical picture, dermatopathology and the finding of anti-MDA5 antibodies finally lead to the diagnosis of amyopathic dermatomyositis with lung involvement.

Translated title of the contributionInitially Amyopathic Dermatomyositis with Lung Involvement and anti-MDA5 Antibodies
Original languageGerman
JournalAktuelle Dermatologie
Issue number1-2
Pages (from-to)59-62
Number of pages4
Publication statusPublished - 2020

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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