TY - JOUR
T1 - Inhibitory effects of methylsulfonylmethane on ventricular hypertrophy related gene expression
AU - Mohammadi, Sadollah
AU - Garjani, Alireza
AU - Najafi, Moslem
AU - Hamzeiy, Hossein
AU - Maleki-Dizaji, Nasrin
AU - Omidi, Yadollah
AU - Fayezi, Shabnam
AU - Darabi, Masoud
AU - Mostafalou, Sara
AU - Hassanzadeh, Kambiz
AU - Khani, Sajjad
PY - 2012
Y1 - 2012
N2 - Methylsulfonylmethane (MSM) is naturally accruing organic sulphur that is known as a potent antiinflammatory compound. The aim of this study was to investigate the effect of MSM on mRNA expressions of angiotensinogen, endothelin-1 (ET-1) and Transforming Growth Factor (TGF)-|3l in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension. Wistar rats were randomly assigned to 38-days pretreatment or 28-days treatment. MSM was administered to either 10 days before or 14 days after a single dose of MCT. Right Ventricle (RV) tissue samples were obtained to evaluate changes in the inflammatory genes expression using RT-PCR assay. The expression levels of angiotensinogen, ET-1 and TGF-|3l significantly were reduced (p<0.01) at efficient dose of MSM in MCT-induced pulmonary arterial hypertensive rats. Results suggest that harmful effects of MCT induced PAH on the RV function could be attenuated by anti-inflammatory actions through the suppression of local RAAS along with associated growth-promoting factors TGF-βl and ET-1.
AB - Methylsulfonylmethane (MSM) is naturally accruing organic sulphur that is known as a potent antiinflammatory compound. The aim of this study was to investigate the effect of MSM on mRNA expressions of angiotensinogen, endothelin-1 (ET-1) and Transforming Growth Factor (TGF)-|3l in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension. Wistar rats were randomly assigned to 38-days pretreatment or 28-days treatment. MSM was administered to either 10 days before or 14 days after a single dose of MCT. Right Ventricle (RV) tissue samples were obtained to evaluate changes in the inflammatory genes expression using RT-PCR assay. The expression levels of angiotensinogen, ET-1 and TGF-|3l significantly were reduced (p<0.01) at efficient dose of MSM in MCT-induced pulmonary arterial hypertensive rats. Results suggest that harmful effects of MCT induced PAH on the RV function could be attenuated by anti-inflammatory actions through the suppression of local RAAS along with associated growth-promoting factors TGF-βl and ET-1.
UR - http://www.scopus.com/inward/record.url?scp=84871991164&partnerID=8YFLogxK
U2 - 10.3923/ijp.2012.647.651
DO - 10.3923/ijp.2012.647.651
M3 - Journal articles
AN - SCOPUS:84871991164
SN - 1811-7775
VL - 8
SP - 647
EP - 651
JO - International Journal of Pharmacology
JF - International Journal of Pharmacology
IS - 7
ER -
