Abstract
Human T-lymphoid cell lines with constitutive intracellular expression of antisense RNA complementary to a 407-bp sequence of the 5' leader-gag region of human immunodeficiency virus type 1 were established by using a nonretroviral expression vector. In cell lines with antisense RNA expression detectable by Northern (RNA) hybridization, human immunodeficiency virus type 1 replication was inhibited to 88% 10 days postinfection and this inhibition lasted 3 weeks postinfection.
| Original language | English |
|---|---|
| Journal | Journal of Virology |
| Volume | 65 |
| Issue number | 1 |
| Pages (from-to) | 468-472 |
| Number of pages | 5 |
| ISSN | 0022-538X |
| DOIs | |
| Publication status | Published - 1991 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Fingerprint
Dive into the research topics of 'Inhibition of human immunodeficiency virus type 1 replication in human T cells stably expressing antisense RNA'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver