Inhibition of erythropoietin production by proinflammatory cytokines

W. Jelkmann, J. Fandrey, H. Pagel


In patients with anemia of chronic diseases plasma level of erythropoietin is often too low in relation to blood hemoglobin concentration. Because infections and inflammatory processes cause activation of cytokine-producing macrophages and lymphocytes, we have carried out in vitro studies to test whether proinflammatory cytokines influence synthesis of erythropoietin. Interleukin 1 (IL-1) and tumor necrosis factor α (TNF-α) proved to suppress erythropoietin production in human hepatoma cell cultures, HepG2 and Hep3B, and in isolated perfused rat kidneys. Interleukin 6 inhibited the production of erythropoietin in the kidney but not in hepatoma cells. These results suggest that immunomodulatory peptides contribute to defective erythropoietin production in renal and non-renal immune diseases.

Original languageEnglish
JournalGematologiya i Transfusiologiya
Issue number1
Pages (from-to)16-19
Number of pages4
Publication statusPublished - 1997

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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