In patients with anemia of chronic diseases plasma level of erythropoietin is often too low in relation to blood hemoglobin concentration. Because infections and inflammatory processes cause activation of cytokine-producing macrophages and lymphocytes, we have carried out in vitro studies to test whether proinflammatory cytokines influence synthesis of erythropoietin. Interleukin 1 (IL-1) and tumor necrosis factor α (TNF-α) proved to suppress erythropoietin production in human hepatoma cell cultures, HepG2 and Hep3B, and in isolated perfused rat kidneys. Interleukin 6 inhibited the production of erythropoietin in the kidney but not in hepatoma cells. These results suggest that immunomodulatory peptides contribute to defective erythropoietin production in renal and non-renal immune diseases.
|Journal||Gematologiya i Transfusiologiya|
|Number of pages||4|
|Publication status||Published - 1997|
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)