TY - JOUR
T1 - Inhibition of cell proliferation, adhesion, and invasion with an anti-L1-cell adhesion molecule monoclonal antibody in an in vitro endometriosis model
AU - Agic, Admir
AU - Von Wussow, Ursula
AU - Starzinski-Powitz, Anna
AU - Diedrich, Klaus
AU - Altevogt, Peter
AU - Hornung, Daniela
PY - 2010/8/1
Y1 - 2010/8/1
N2 - The use of anti-L1-cell adhesion molecule monoclonal antibodies (anti-L1CAM-mAb) in an endometriosis epithelial cell line Z12 led to a statistically significant decrease in cell proliferation and cell invasion and to an inhibition of the adhesion compared with unspecific IgG-Ab treated and untreated cells. Because it increases the cell invasion and adhesion which consequently aggravates the disease, L1 could possibly promote endometriosis development; thus, further studies should evaluate the possible use of anti-L1-mAb in an animal endometriosis model.
AB - The use of anti-L1-cell adhesion molecule monoclonal antibodies (anti-L1CAM-mAb) in an endometriosis epithelial cell line Z12 led to a statistically significant decrease in cell proliferation and cell invasion and to an inhibition of the adhesion compared with unspecific IgG-Ab treated and untreated cells. Because it increases the cell invasion and adhesion which consequently aggravates the disease, L1 could possibly promote endometriosis development; thus, further studies should evaluate the possible use of anti-L1-mAb in an animal endometriosis model.
UR - http://www.scopus.com/inward/record.url?scp=77955566632&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2009.11.050
DO - 10.1016/j.fertnstert.2009.11.050
M3 - Journal articles
C2 - 20137787
AN - SCOPUS:77955566632
SN - 0015-0282
VL - 94
SP - 1102
EP - 1104
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 3
ER -
