Influence of factor substitution on the B-cell response in hemophiliacs.

J. Kekow*, H. Plendl, W. L. Gross

*Corresponding author for this work


Studies in hemophiliacs receiving factor concentrates demonstrated T-cell defects in vitro. Recently, B-cell dysfunctions were described in AIDS and pre-AIDS and in some hemophiliacs. To investigate the B-cell function in hemophiliacs in relation to factor substitution, we examined five patients with mild (substitution less than 20,000 U/year) and seven with severe (greater than 100,000 U/year) hemophilia A and compared the data with normal control individuals. The B-cell proliferative response (3H-thymidine uptake) to Staphylococcus aureus Cowan I and the differentiation response (Ig secretion into culture supernatants) to T-cell-dependent or -independent polyclonal B-cell activators (PBAs) were studied in vitro. In contrast to T-cell dysfunctions, which correlate with the amount of clotting factor concentrates, the B-cell proliferative response was not affected. Stimulation with PBAs however failed to increase elevated spontaneous IgG levels and showed a diminished increase in IgM levels in severe, but not in mild, hemophilia. Our data give evidence of a T-cell-independent B-cell dysfunction in asymptomatic hemophiliacs that correlates with factor substitution.

Original languageEnglish
JournalCancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc
Pages (from-to)43-49
Number of pages7
Publication statusPublished - 1987

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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