Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments

Katharina Herrmann, Christian Flöhr, Jens Stalljohann, Gabriela Apiou-Sbirlea, Jochen Kandulla, Reginald Birngruber, Ralf Brinkmann


In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.

Original languageEnglish
Title of host publicationTherapeutic Laser Applications and Laser-Tissue Interactions III
EditorsAlfred Vogel
Number of pages7
PublisherOptical Society of America
Publication date13.07.2007
ISBN (Print)978-081946771-3
Publication statusPublished - 13.07.2007
EventEuropean Conference on Biomedical Optics 2007 - Munich, Germany
Duration: 17.06.200717.06.2007
Conference number: 104705

Research Areas and Centers

  • Academic Focus: Biomedical Engineering


Dive into the research topics of 'Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments'. Together they form a unique fingerprint.

Cite this