Influence of biperiden and bomaprine on sleep in healthy subjects

Fritz Hohagen; Stephanie Lis; Dieter Riemann; Stephan Krieger; C. Meyer; Rosemarie Fritsch Montero; Heinz Crunze; Mathias Berger

doi:10.1038/npp.1994.33

Influence of biperiden and bomaprine on sleep in healthy subjects

Fritz Hohagen^*, Stephanie Lis, Dieter Riemann, Stephan Krieger, C. Meyer, Rosemarie Fritsch Montero, Heinz Crunze, Mathias Berger

^*Corresponding author for this work

Department of Psychiatry, Psychosomatics and Psychotherapie

University of Freiburg

8 Citations (Scopus)

Abstract

Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the Ml receptor subtype, and bornaprine, 4 mg, a nonselective Ml and M2 antagonist, were administered orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on polysomnographically recorded sleep. Both drugs suppressed rapid eye movement (REM) sleep as reflected by an increase of REM latency and a decrease in the percentage of REM sleep period time with the effects of biperiden being more pronounced. No significant effect on slow wave sleep was observed. The results of this study support the hypothesis that both the Ml and the M2 receptor subtype are involved in the regulation of REM sleep in humans.

Original language	English
Journal	Neuropsychopharmacology
Volume	11
Issue number	1
Pages (from-to)	29-32
Number of pages	4
ISSN	0893-133X
DOIs	https://doi.org/10.1038/npp.1994.33
Publication status	Published - 08.1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1038/npp.1994.33

Cite this

@article{7a3ef8aa03224d3ba44d53e8b8dcd773,

title = "Influence of biperiden and bomaprine on sleep in healthy subjects",

abstract = "Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the Ml receptor subtype, and bornaprine, 4 mg, a nonselective Ml and M2 antagonist, were administered orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on polysomnographically recorded sleep. Both drugs suppressed rapid eye movement (REM) sleep as reflected by an increase of REM latency and a decrease in the percentage of REM sleep period time with the effects of biperiden being more pronounced. No significant effect on slow wave sleep was observed. The results of this study support the hypothesis that both the Ml and the M2 receptor subtype are involved in the regulation of REM sleep in humans.",

author = "Fritz Hohagen and Stephanie Lis and Dieter Riemann and Stephan Krieger and C. Meyer and Montero, \{Rosemarie Fritsch\} and Heinz Crunze and Mathias Berger",

year = "1994",

month = aug,

doi = "10.1038/npp.1994.33",

language = "English",

volume = "11",

pages = "29--32",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Influence of biperiden and bomaprine on sleep in healthy subjects

AU - Hohagen, Fritz

AU - Lis, Stephanie

AU - Riemann, Dieter

AU - Krieger, Stephan

AU - Meyer, C.

AU - Montero, Rosemarie Fritsch

AU - Crunze, Heinz

AU - Berger, Mathias

PY - 1994/8

Y1 - 1994/8

N2 - Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the Ml receptor subtype, and bornaprine, 4 mg, a nonselective Ml and M2 antagonist, were administered orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on polysomnographically recorded sleep. Both drugs suppressed rapid eye movement (REM) sleep as reflected by an increase of REM latency and a decrease in the percentage of REM sleep period time with the effects of biperiden being more pronounced. No significant effect on slow wave sleep was observed. The results of this study support the hypothesis that both the Ml and the M2 receptor subtype are involved in the regulation of REM sleep in humans.

AB - Biperiden, 4 mg, an anticholinergic drug that is relatively selective for the Ml receptor subtype, and bornaprine, 4 mg, a nonselective Ml and M2 antagonist, were administered orally in a randomized, double-blind design to twelve healthy volunteers to investigate the effect on polysomnographically recorded sleep. Both drugs suppressed rapid eye movement (REM) sleep as reflected by an increase of REM latency and a decrease in the percentage of REM sleep period time with the effects of biperiden being more pronounced. No significant effect on slow wave sleep was observed. The results of this study support the hypothesis that both the Ml and the M2 receptor subtype are involved in the regulation of REM sleep in humans.

UR - https://www.scopus.com/pages/publications/0027935734

U2 - 10.1038/npp.1994.33

DO - 10.1038/npp.1994.33

M3 - Journal articles

C2 - 7945741

AN - SCOPUS:0027935734

SN - 0893-133X

VL - 11

SP - 29

EP - 32

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 1

ER -

Influence of biperiden and bomaprine on sleep in healthy subjects

Abstract

UN SDGs

Research Areas and Centers

Access to Document

Other files and links

Fingerprint

Cite this