Inflammation-Promoting Complement Fragments

D. Bitter-Suermann; J. Köhl

doi:10.1007/978-3-642-83755-5_25

Inflammation-Promoting Complement Fragments

D. Bitter-Suermann, J. Köhl

Institute of Systemic Inflamation Research

Abstract

The bulk of inflammatory potential of the complement system is characterized by the following items:
1.
Along the reaction sequence of the complement system split products (activation peptides) of well characterized complement proteins are generated and released which by themselves don’t influence the further activation cascade. But, as soluble factors they represent one of the three major effector mechanisms mediated by complement, i.e. inflammation.

2.
The other mechanisms are adherence, antigen- and IC-processing mediated via complement receptors for the covalently fixed C3b, iC3b and C3d, and cytolysis mediated by the membrane inserted terminal complex C5b-9 (membrane attack complex). Adherence to and membrane perturbation by C3b fragments and C5b-9 respectively contribute to pathologic sequelae exerted by actively attracted and passively affected cells in the inflammatory situation.

Original language	English
Title of host publication	Progress in Immunology
Editors	Fritz Melchers, E. D. Albert, H. von Boehmer, M. P. Dierich, L. Du Pasquier, K. Eichmann, D. Gemsa, O. Götze, J. R. Kalden, S. H. E. Kaufmann, H. Kirchner, K. Resch, G. Riethmüller, A. Schimpl, C. Sorg, M. Steinmetz, H. Wagner, H. G. Zachau
Number of pages	8
Place of Publication	Berlin, Heidelberg
Publisher	Springer Berlin Heidelberg
Publication date	1989
Pages	186-193
ISBN (Print)	978-3-642-83757-9
ISBN (Electronic)	978-3-642-83755-5
DOIs	https://doi.org/10.1007/978-3-642-83755-5_25
Publication status	Published - 1989
Event	Proceedings of the 7th International Congress Immunology Berlin 1989 - berlin, Germany Duration: 01.01.1989 → 01.01.1989

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10.1007/978-3-642-83755-5_25

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Bitter-Suermann, D., & Köhl, J. (1989). Inflammation-Promoting Complement Fragments. In F. Melchers, E. D. Albert, H. von Boehmer, M. P. Dierich, L. Du Pasquier, K. Eichmann, D. Gemsa, O. Götze, J. R. Kalden, S. H. E. Kaufmann, H. Kirchner, K. Resch, G. Riethmüller, A. Schimpl, C. Sorg, M. Steinmetz, H. Wagner, & H. G. Zachau (Eds.), Progress in Immunology (pp. 186-193). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_25

Bitter-Suermann, D. ; Köhl, J. / Inflammation-Promoting Complement Fragments. Progress in Immunology. editor / Fritz Melchers ; E. D. Albert ; H. von Boehmer ; M. P. Dierich ; L. Du Pasquier ; K. Eichmann ; D. Gemsa ; O. Götze ; J. R. Kalden ; S. H. E. Kaufmann ; H. Kirchner ; K. Resch ; G. Riethmüller ; A. Schimpl ; C. Sorg ; M. Steinmetz ; H. Wagner ; H. G. Zachau. Berlin, Heidelberg : Springer Berlin Heidelberg, 1989. pp. 186-193

@inproceedings{9a7fcc6711104cc4a7bf0d826a6f0348,

title = "Inflammation-Promoting Complement Fragments",

abstract = "The bulk of inflammatory potential of the complement system is characterized by the following items:1.Along the reaction sequence of the complement system split products (activation peptides) of well characterized complement proteins are generated and released which by themselves don{\textquoteright}t influence the further activation cascade. But, as soluble factors they represent one of the three major effector mechanisms mediated by complement, i.e. inflammation.2.The other mechanisms are adherence, antigen- and IC-processing mediated via complement receptors for the covalently fixed C3b, iC3b and C3d, and cytolysis mediated by the membrane inserted terminal complex C5b-9 (membrane attack complex). Adherence to and membrane perturbation by C3b fragments and C5b-9 respectively contribute to pathologic sequelae exerted by actively attracted and passively affected cells in the inflammatory situation.",

author = "D. Bitter-Suermann and J. K{\"o}hl",

year = "1989",

doi = "10.1007/978-3-642-83755-5_25",

language = "English",

isbn = "978-3-642-83757-9",

pages = "186--193",

editor = "Fritz Melchers and Albert, {E. D.} and {von Boehmer}, H. and Dierich, {M. P.} and {Du Pasquier}, L. and K. Eichmann and D. Gemsa and O. G{\"o}tze and Kalden, {J. R.} and Kaufmann, {S. H. E.} and H. Kirchner and K. Resch and G. Riethm{\"u}ller and A. Schimpl and C. Sorg and M. Steinmetz and H. Wagner and Zachau, {H. G.}",

booktitle = "Progress in Immunology",

publisher = "Springer Berlin Heidelberg",

note = "Proceedings of the 7th International Congress Immunology Berlin 1989 ; Conference date: 01-01-1989 Through 01-01-1989",

}

Bitter-Suermann, D & Köhl, J 1989, Inflammation-Promoting Complement Fragments. in F Melchers, ED Albert, H von Boehmer, MP Dierich, L Du Pasquier, K Eichmann, D Gemsa, O Götze, JR Kalden, SHE Kaufmann, H Kirchner, K Resch, G Riethmüller, A Schimpl, C Sorg, M Steinmetz, H Wagner & HG Zachau (eds), Progress in Immunology. Springer Berlin Heidelberg, Berlin, Heidelberg, pp. 186-193, Proceedings of the 7th International Congress Immunology Berlin 1989, berlin, Berlin, Germany, 01.01.89. https://doi.org/10.1007/978-3-642-83755-5_25

Inflammation-Promoting Complement Fragments. / Bitter-Suermann, D.; Köhl, J.
Progress in Immunology. ed. / Fritz Melchers; E. D. Albert; H. von Boehmer; M. P. Dierich; L. Du Pasquier; K. Eichmann; D. Gemsa; O. Götze; J. R. Kalden; S. H. E. Kaufmann; H. Kirchner; K. Resch; G. Riethmüller; A. Schimpl; C. Sorg; M. Steinmetz; H. Wagner; H. G. Zachau. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. p. 186-193.

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

TY - GEN

T1 - Inflammation-Promoting Complement Fragments

AU - Bitter-Suermann, D.

AU - Köhl, J.

PY - 1989

Y1 - 1989

N2 - The bulk of inflammatory potential of the complement system is characterized by the following items:1.Along the reaction sequence of the complement system split products (activation peptides) of well characterized complement proteins are generated and released which by themselves don’t influence the further activation cascade. But, as soluble factors they represent one of the three major effector mechanisms mediated by complement, i.e. inflammation.2.The other mechanisms are adherence, antigen- and IC-processing mediated via complement receptors for the covalently fixed C3b, iC3b and C3d, and cytolysis mediated by the membrane inserted terminal complex C5b-9 (membrane attack complex). Adherence to and membrane perturbation by C3b fragments and C5b-9 respectively contribute to pathologic sequelae exerted by actively attracted and passively affected cells in the inflammatory situation.

AB - The bulk of inflammatory potential of the complement system is characterized by the following items:1.Along the reaction sequence of the complement system split products (activation peptides) of well characterized complement proteins are generated and released which by themselves don’t influence the further activation cascade. But, as soluble factors they represent one of the three major effector mechanisms mediated by complement, i.e. inflammation.2.The other mechanisms are adherence, antigen- and IC-processing mediated via complement receptors for the covalently fixed C3b, iC3b and C3d, and cytolysis mediated by the membrane inserted terminal complex C5b-9 (membrane attack complex). Adherence to and membrane perturbation by C3b fragments and C5b-9 respectively contribute to pathologic sequelae exerted by actively attracted and passively affected cells in the inflammatory situation.

U2 - 10.1007/978-3-642-83755-5_25

DO - 10.1007/978-3-642-83755-5_25

M3 - Conference contribution

SN - 978-3-642-83757-9

SP - 186

EP - 193

BT - Progress in Immunology

A2 - Melchers, Fritz

A2 - Albert, E. D.

A2 - von Boehmer, H.

A2 - Dierich, M. P.

A2 - Du Pasquier, L.

A2 - Eichmann, K.

A2 - Gemsa, D.

A2 - Götze, O.

A2 - Kalden, J. R.

A2 - Kaufmann, S. H. E.

A2 - Kirchner, H.

A2 - Resch, K.

A2 - Riethmüller, G.

A2 - Schimpl, A.

A2 - Sorg, C.

A2 - Steinmetz, M.

A2 - Wagner, H.

A2 - Zachau, H. G.

PB - Springer Berlin Heidelberg

CY - Berlin, Heidelberg

T2 - Proceedings of the 7th International Congress Immunology Berlin 1989

Y2 - 1 January 1989 through 1 January 1989

ER -

Bitter-Suermann D, Köhl J. Inflammation-Promoting Complement Fragments. In Melchers F, Albert ED, von Boehmer H, Dierich MP, Du Pasquier L, Eichmann K, Gemsa D, Götze O, Kalden JR, Kaufmann SHE, Kirchner H, Resch K, Riethmüller G, Schimpl A, Sorg C, Steinmetz M, Wagner H, Zachau HG, editors, Progress in Immunology. Berlin, Heidelberg: Springer Berlin Heidelberg. 1989. p. 186-193 doi: 10.1007/978-3-642-83755-5_25

Inflammation-Promoting Complement Fragments

Abstract

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