Inflammation-Promoting Complement Fragments

D. Bitter-Suermann, J. Köhl


    The bulk of inflammatory potential of the complement system is characterized by the following items:
    Along the reaction sequence of the complement system split products (activation peptides) of well characterized complement proteins are generated and released which by themselves don’t influence the further activation cascade. But, as soluble factors they represent one of the three major effector mechanisms mediated by complement, i.e. inflammation.

    The other mechanisms are adherence, antigen- and IC-processing mediated via complement receptors for the covalently fixed C3b, iC3b and C3d, and cytolysis mediated by the membrane inserted terminal complex C5b-9 (membrane attack complex). Adherence to and membrane perturbation by C3b fragments and C5b-9 respectively contribute to pathologic sequelae exerted by actively attracted and passively affected cells in the inflammatory situation.
    Original languageEnglish
    Title of host publicationProgress in Immunology
    EditorsFritz Melchers, E. D. Albert, H. von Boehmer, M. P. Dierich, L. Du Pasquier, K. Eichmann, D. Gemsa, O. Götze, J. R. Kalden, S. H. E. Kaufmann, H. Kirchner, K. Resch, G. Riethmüller, A. Schimpl, C. Sorg, M. Steinmetz, H. Wagner, H. G. Zachau
    Number of pages8
    Place of PublicationBerlin, Heidelberg
    PublisherSpringer Berlin Heidelberg
    Publication date1989
    ISBN (Print)978-3-642-83757-9
    ISBN (Electronic)978-3-642-83755-5
    Publication statusPublished - 1989
    EventProceedings of the 7th International Congress Immunology Berlin 1989 - berlin, Germany
    Duration: 01.01.198901.01.1989


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