TY - JOUR
T1 - Inducible and combinatorial gene manipulation in mouse brain
AU - Dogbevia, Godwin K.
AU - Marticorena-Alvarez, Ricardo
AU - Bausen, Melanie
AU - Sprengel, Rolf
AU - Hasan, Mazahir T.
PY - 2015/4/21
Y1 - 2015/4/21
N2 - We have deployed recombinant adeno-associated viruses equipped with tetracyclinecontrolled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemicalgenetic approach will help to investigate ‘when’, ‘where’, and ‘how’ gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.
AB - We have deployed recombinant adeno-associated viruses equipped with tetracyclinecontrolled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemicalgenetic approach will help to investigate ‘when’, ‘where’, and ‘how’ gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.
UR - http://www.scopus.com/inward/record.url?scp=84929587359&partnerID=8YFLogxK
U2 - 10.3389/fncel.2015.00142
DO - 10.3389/fncel.2015.00142
M3 - Journal articles
AN - SCOPUS:84929587359
SN - 1662-5102
VL - 9
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
IS - APR
ER -
