Abstract
Albuterol, a specific β-2 adre-nergic agonist, was found to produce a significant increase in perfusate levels of Ep in isolated perfused dog kidneys which were programmed by prior exposure to hypoxia (0.42 atm) for 2 hr. Albuterol enhanced Ep titers in perfusates in both normoxemic and hypoxemic perfused kidneys which were significantly higher than that of the Ep level seen in saline controls during a 5-hr perfusion period. The effect of albuterol on Ep production in isolated perfused kidneys was abolished by pretreatment of the dogs with the prostaglandins synthetase inhibitor indo-methacin. The inhibition of albuterol-in-duced Ep elaboration by indomethacin supports our hypothesis that prostaglandins may play a significant role in mediating β-2 ad-renergic activation of kidney Ep production.
| Original language | English |
|---|---|
| Journal | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.) |
| Volume | 162 |
| Issue number | 1 |
| Pages (from-to) | 65-70 |
| Number of pages | 6 |
| ISSN | 0037-9727 |
| DOIs | |
| Publication status | Published - 10.1979 |
Funding
This work was supported by USPHS Grant AM 13211. Wolfgang Jelkmann was a postdoctoral fellow from the Department of Physiology, University of Re-gensburg, supported by the Deutsche Forschungsge-meinschaft, West Germany.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
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