TY - JOUR
T1 - Indomethacin Blockade of Albuterol-lnduced Erythropoietin Production in Isolated Perfused Dog Kidneys
AU - Jelkmann, Wolfgang
AU - Brookins, Jesse
AU - Fisher, James W.
N1 - Funding Information:
This work was supported by USPHS Grant AM 13211. Wolfgang Jelkmann was a postdoctoral fellow from the Department of Physiology, University of Re-gensburg, supported by the Deutsche Forschungsge-meinschaft, West Germany.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1979/10
Y1 - 1979/10
N2 - Albuterol, a specific β-2 adre-nergic agonist, was found to produce a significant increase in perfusate levels of Ep in isolated perfused dog kidneys which were programmed by prior exposure to hypoxia (0.42 atm) for 2 hr. Albuterol enhanced Ep titers in perfusates in both normoxemic and hypoxemic perfused kidneys which were significantly higher than that of the Ep level seen in saline controls during a 5-hr perfusion period. The effect of albuterol on Ep production in isolated perfused kidneys was abolished by pretreatment of the dogs with the prostaglandins synthetase inhibitor indo-methacin. The inhibition of albuterol-in-duced Ep elaboration by indomethacin supports our hypothesis that prostaglandins may play a significant role in mediating β-2 ad-renergic activation of kidney Ep production.
AB - Albuterol, a specific β-2 adre-nergic agonist, was found to produce a significant increase in perfusate levels of Ep in isolated perfused dog kidneys which were programmed by prior exposure to hypoxia (0.42 atm) for 2 hr. Albuterol enhanced Ep titers in perfusates in both normoxemic and hypoxemic perfused kidneys which were significantly higher than that of the Ep level seen in saline controls during a 5-hr perfusion period. The effect of albuterol on Ep production in isolated perfused kidneys was abolished by pretreatment of the dogs with the prostaglandins synthetase inhibitor indo-methacin. The inhibition of albuterol-in-duced Ep elaboration by indomethacin supports our hypothesis that prostaglandins may play a significant role in mediating β-2 ad-renergic activation of kidney Ep production.
UR - http://www.scopus.com/inward/record.url?scp=0018565015&partnerID=8YFLogxK
U2 - 10.3181/00379727-162-40619
DO - 10.3181/00379727-162-40619
M3 - Journal articles
C2 - 228314
AN - SCOPUS:0018565015
SN - 0037-9727
VL - 162
SP - 65
EP - 70
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 1
ER -