Indomethacin Blockade of Albuterol-lnduced Erythropoietin Production in Isolated Perfused Dog Kidneys

Wolfgang Jelkmann, Jesse Brookins, James W. Fisher

6 Citations (Scopus)

Abstract

Albuterol, a specific β-2 adre-nergic agonist, was found to produce a significant increase in perfusate levels of Ep in isolated perfused dog kidneys which were programmed by prior exposure to hypoxia (0.42 atm) for 2 hr. Albuterol enhanced Ep titers in perfusates in both normoxemic and hypoxemic perfused kidneys which were significantly higher than that of the Ep level seen in saline controls during a 5-hr perfusion period. The effect of albuterol on Ep production in isolated perfused kidneys was abolished by pretreatment of the dogs with the prostaglandins synthetase inhibitor indo-methacin. The inhibition of albuterol-in-duced Ep elaboration by indomethacin supports our hypothesis that prostaglandins may play a significant role in mediating β-2 ad-renergic activation of kidney Ep production.

Original languageEnglish
JournalProceedings of the Society for Experimental Biology and Medicine
Volume162
Issue number1
Pages (from-to)65-70
Number of pages6
ISSN0037-9727
DOIs
Publication statusPublished - 10.1979

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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