Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Lars Nyberg; Micael Andersson; Anders Lundquist; William F.C. Baaré; David Bartrés-Faz; Lars Bertram; Carl Johan Boraxbekk; Andreas M. Brandmaier; Naiara Demnitz; Christian A. Drevon; Sandra Duezel; Klaus P. Ebmeier; Paolo Ghisletta; Richard Henson; Daria E.A. Jensen; Rogier A. Kievit; Ethan Knights; Simone Kühn; Ulman Lindenberger; Anna Plachti; Sara Pudas; James M. Roe; Kathrine Skak Madsen; Cristina Solé-Padullés; Yasmine Sommerer; Sana Suri; Eniko Zsoldos; Anders M. Fjell; Kristine B. Walhovd

doi:10.1093/cercor/bhac400

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Lars Nyberg^*, Micael Andersson, Anders Lundquist, William F.C. Baaré, David Bartrés-Faz, Lars Bertram, Carl Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E.A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Anna PlachtiSara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Solé-Padullés, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd

^*Corresponding author for this work

Institute of Neurogenetics

19 Citations (Scopus)

Abstract

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Original language	English
Journal	Cerebral Cortex
Volume	33
Issue number	9
Pages (from-to)	5075-5081
Number of pages	7
ISSN	1047-3211
DOIs	https://doi.org/10.1093/cercor/bhac400
Publication status	Published - 01.05.2023

Funding

The Lifebrain project is funded by the EU Horizon 2020 (grant agreement number 732592). L.N. is supported by a scholar grant from the Knut and Alice Wallenberg foundation.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Nyberg, L., Andersson, M., Lundquist, A., Baaré, W. F. C., Bartrés-Faz, D., Bertram, L., Boraxbekk, C. J., Brandmaier, A. M., Demnitz, N., Drevon, C. A., Duezel, S., Ebmeier, K. P., Ghisletta, P., Henson, R., Jensen, D. E. A., Kievit, R. A., Knights, E., Kühn, S., Lindenberger, U., ... Walhovd, K. B. (2023). Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates. Cerebral Cortex, 33(9), 5075-5081. https://doi.org/10.1093/cercor/bhac400

@article{4333570068954d0b9a70bffaae68859a,

title = "Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates",

abstract = "It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.",

author = "Lars Nyberg and Micael Andersson and Anders Lundquist and Baar{\'e}, \{William F.C.\} and David Bartr{\'e}s-Faz and Lars Bertram and Boraxbekk, \{Carl Johan\} and Brandmaier, \{Andreas M.\} and Naiara Demnitz and Drevon, \{Christian A.\} and Sandra Duezel and Ebmeier, \{Klaus P.\} and Paolo Ghisletta and Richard Henson and Jensen, \{Daria E.A.\} and Kievit, \{Rogier A.\} and Ethan Knights and Simone K{\"u}hn and Ulman Lindenberger and Anna Plachti and Sara Pudas and Roe, \{James M.\} and Madsen, \{Kathrine Skak\} and Cristina Sol{\'e}-Padull{\'e}s and Yasmine Sommerer and Sana Suri and Eniko Zsoldos and Fjell, \{Anders M.\} and Walhovd, \{Kristine B.\}",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press.",

year = "2023",

month = may,

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doi = "10.1093/cercor/bhac400",

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Nyberg, L, Andersson, M, Lundquist, A, Baaré, WFC, Bartrés-Faz, D, Bertram, L, Boraxbekk, CJ, Brandmaier, AM, Demnitz, N, Drevon, CA, Duezel, S, Ebmeier, KP, Ghisletta, P, Henson, R, Jensen, DEA, Kievit, RA, Knights, E, Kühn, S, Lindenberger, U, Plachti, A, Pudas, S, Roe, JM, Madsen, KS, Solé-Padullés, C, Sommerer, Y, Suri, S, Zsoldos, E, Fjell, AM & Walhovd, KB 2023, 'Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates', Cerebral Cortex, vol. 33, no. 9, pp. 5075-5081. https://doi.org/10.1093/cercor/bhac400

TY - JOUR

T1 - Individual differences in brain aging

T2 - heterogeneity in cortico-hippocampal but not caudate atrophy rates

AU - Nyberg, Lars

AU - Andersson, Micael

AU - Lundquist, Anders

AU - Baaré, William F.C.

AU - Bartrés-Faz, David

AU - Bertram, Lars

AU - Boraxbekk, Carl Johan

AU - Brandmaier, Andreas M.

AU - Demnitz, Naiara

AU - Drevon, Christian A.

AU - Duezel, Sandra

AU - Ebmeier, Klaus P.

AU - Ghisletta, Paolo

AU - Henson, Richard

AU - Jensen, Daria E.A.

AU - Kievit, Rogier A.

AU - Knights, Ethan

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Plachti, Anna

AU - Pudas, Sara

AU - Roe, James M.

AU - Madsen, Kathrine Skak

AU - Solé-Padullés, Cristina

AU - Sommerer, Yasmine

AU - Suri, Sana

AU - Zsoldos, Eniko

AU - Fjell, Anders M.

AU - Walhovd, Kristine B.

PY - 2023/5/1

Y1 - 2023/5/1

N2 - It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

AB - It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

UR - https://www.scopus.com/pages/publications/85159256770

UR - https://www.mendeley.com/catalogue/c94c0e60-b40e-33ac-b51a-49c17d67709d/

U2 - 10.1093/cercor/bhac400

DO - 10.1093/cercor/bhac400

M3 - Journal articles

C2 - 36197324

AN - SCOPUS:85159256770

SN - 1047-3211

VL - 33

SP - 5075

EP - 5081

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 9

ER -

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Abstract

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UN SDGs

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