Increasing Seizure Activity during Radiation Treatment for High-grade Gliomas - Final Results of a Prospective Interventional Study

Dirk Rades*, Jaspar Witteler, Peter Trillenberg, Denise Olbrich, Steven E. Schild, Søren Tvilsted, Troels W. Kjaer

*Corresponding author for this work
1 Citation (Scopus)

Abstract

Background/Aim: Little is known regarding seizures during radiotherapy for brain tumors. This prospective study investigated seizure activity in patients irradiated for high-grade gliomas. Patients and Methods: Using a seizure diary, progression of seizure activity was evaluated in 22 patients receiving chemoradiation for grade III (n=1) or IV (n=21) gliomas. Progression was defined as increased frequency of any and/or generalized seizures (>50%) or increased anti-epileptic medication (≥25%). Patients’ satisfaction with the diary was assessed using a questionnaire (six scales of 1-7 points). Uni- and multivariable analyses were performed including baseline seizure activity, age, sex, resection, tumor site, performance score, and history of epilepsy/seizures. Results: Ten patients (45%) experienced progression of seizure activity during their radiotherapy course, mainly due to increased seizure frequency (nine patients=41%). Mean values of patients’ satisfaction scores ranged between 3.92 and 4.92 points. Conclusion: Radiotherapy of high-grade gliomas can increase seizure activity. Patients require close monitoring to initiate or adjust anti-epileptic medication.

Original languageEnglish
JournalIn Vivo
Volume36
Issue number5
Pages (from-to)2308-2313
Number of pages6
ISSN0258-851X
DOIs
Publication statusPublished - 09.2022

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)

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