TY - JOUR
T1 - Increasing mean age of head and neck cancer patients at a german tertiary referral center
AU - Vahl, Julius M.
AU - Wigand, Marlene C.
AU - Denkinger, Michael
AU - Dallmeier, Dhayana
AU - Steiger, Chiara
AU - Welke, Claudia
AU - Kuhn, Peter
AU - Idel, Christian
AU - Doescher, Johannes
AU - Witzleben, Adrian von
AU - Brand, Matthias
AU - Marienfeld, Ralf
AU - Möller, Peter
AU - Theodoraki, Marie Nicole
AU - Greve, Jens
AU - Schuler, Patrick J.
AU - Brunner, Cornelia
AU - Hoffmann, Thomas K.
AU - Laban, Simon
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/2/17
Y1 - 2021/2/17
N2 - Background: The impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging trends in HNC at a tertiary referral center. Methods: Retrospective cohort study on aging trends at the initial diagnosis of newly diagnosed patients with HNC between 2004 and 2018 at the head and neck cancer center Ulm in relation to demographic data of the catchment area. Results: The study population consisted of 2450 individuals diagnosed with HNC with a mean age of 62.84 (±11.67) years. We observed a significant increase in annual incidence rates and mean age over time. Mean age among HNC patients increased significantly more than among the population in the catchment area. Whereas the incidence rate of patients <50 years did not change, the incidence of HNC patients aged ≥70 years increased the most. The mean patient age in the main tumor sites increased significantly. Surprisingly, HPV-positive patients were not younger than HPV-negative patients, but showed a non-significant trend towards a higher mean age (63.0 vs. 60.7 years). Conclusions: Increasing incidence rates in older patients pose a challenge for health care systems. A nationwide study is needed to assess the dynamics and impact of aging on the incidence of HNC.
AB - Background: The impact of demographic change on the age at diagnosis in German head and neck cancer (HNC) patients is unclear. Here we present an evaluation of aging trends in HNC at a tertiary referral center. Methods: Retrospective cohort study on aging trends at the initial diagnosis of newly diagnosed patients with HNC between 2004 and 2018 at the head and neck cancer center Ulm in relation to demographic data of the catchment area. Results: The study population consisted of 2450 individuals diagnosed with HNC with a mean age of 62.84 (±11.67) years. We observed a significant increase in annual incidence rates and mean age over time. Mean age among HNC patients increased significantly more than among the population in the catchment area. Whereas the incidence rate of patients <50 years did not change, the incidence of HNC patients aged ≥70 years increased the most. The mean patient age in the main tumor sites increased significantly. Surprisingly, HPV-positive patients were not younger than HPV-negative patients, but showed a non-significant trend towards a higher mean age (63.0 vs. 60.7 years). Conclusions: Increasing incidence rates in older patients pose a challenge for health care systems. A nationwide study is needed to assess the dynamics and impact of aging on the incidence of HNC.
UR - http://www.scopus.com/inward/record.url?scp=85101076864&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/9b29ce50-e2ff-3390-8de0-57a0fa99fe1a/
U2 - 10.3390/cancers13040832
DO - 10.3390/cancers13040832
M3 - Journal articles
C2 - 33671152
AN - SCOPUS:85101076864
SN - 2072-6694
VL - 13
SP - 1
EP - 10
JO - Cancers
JF - Cancers
IS - 4
M1 - 832
ER -
