Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Jannik Prasuhn; Martin Göttlich; Sinja S. Großer; Katharina Reuther; Britt Ebeling; Christina Bodemann; Henrike Hanssen; Armin M. Nagel; Norbert Brüggemann

doi:10.3390/biomedicines10071728

Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Jannik Prasuhn, Martin Göttlich, Sinja S. Großer, Katharina Reuther, Britt Ebeling, Christina Bodemann, Henrike Hanssen, Armin M. Nagel, Norbert Brüggemann^*

^*Corresponding author for this work

2 Citations (Scopus)

Abstract

Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (²³Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) ²³Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. ²³Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

Original language	English
Article number	1728
Journal	Biomedicines
Volume	10
Issue number	7
ISSN	2227-9059
DOIs	https://doi.org/10.3390/biomedicines10071728
Publication status	Published - 07.2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

2.23-07 Clinical Neurology, Neurosurgery and Neuroradiology

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10.3390/biomedicines10071728

Cite this

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title = "Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy",

abstract = "Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.",

author = "Jannik Prasuhn and Martin G{\"o}ttlich and Gro{\ss}er, \{Sinja S.\} and Katharina Reuther and Britt Ebeling and Christina Bodemann and Henrike Hanssen and Nagel, \{Armin M.\} and Norbert Br{\"u}ggemann",

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year = "2022",

month = jul,

doi = "10.3390/biomedicines10071728",

language = "English",

volume = "10",

journal = "Biomedicines",

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TY - JOUR

T1 - Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

AU - Prasuhn, Jannik

AU - Göttlich, Martin

AU - Großer, Sinja S.

AU - Reuther, Katharina

AU - Ebeling, Britt

AU - Bodemann, Christina

AU - Hanssen, Henrike

AU - Nagel, Armin M.

AU - Brüggemann, Norbert

PY - 2022/7

Y1 - 2022/7

N2 - Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

AB - Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

UR - https://www.scopus.com/pages/publications/85137284490

U2 - 10.3390/biomedicines10071728

DO - 10.3390/biomedicines10071728

M3 - Journal articles

AN - SCOPUS:85137284490

SN - 2227-9059

VL - 10

JO - Biomedicines

JF - Biomedicines

IS - 7

M1 - 1728

ER -

Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Abstract

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