Increased non-angiotensin II [125I]CGP 42112 binding in rat carotid artery after balloon injury

M Viswanathan; O Jöhren; M de Oliveira; J M Saavedra

Increased non-angiotensin II [125I]CGP 42112 binding in rat carotid artery after balloon injury

M Viswanathan, O Jöhren, M de Oliveira, J M Saavedra

Institute of Experimental and Clinical Pharmacology and Toxicology

National Institutes of Health

Abstract

In this study, [125I]CGP 42112, a ligand of high affinity and selectivity for the angiotensin II AT2 receptor, was used to detect and quantify a non-angiotensin II binding site in the balloon-injured carotid artery of the rat. The amount of [125I]CGP 42112 binding was significantly enhanced in the adventitia of the injured arteries. Localization of the binding site using emulsion autoradiography and immunocytochemistry suggests that the binding sites may be expressed by macrophages in the inflamed tissue surrounding the injured artery.

Original language	English
Journal	Peptides
Volume	17
Issue number	4
Pages (from-to)	695-9
Number of pages	5
ISSN	0196-9781
Publication status	Published - 1996

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title = "Increased non-angiotensin II [125I]CGP 42112 binding in rat carotid artery after balloon injury",

abstract = "In this study, [125I]CGP 42112, a ligand of high affinity and selectivity for the angiotensin II AT2 receptor, was used to detect and quantify a non-angiotensin II binding site in the balloon-injured carotid artery of the rat. The amount of [125I]CGP 42112 binding was significantly enhanced in the adventitia of the injured arteries. Localization of the binding site using emulsion autoradiography and immunocytochemistry suggests that the binding sites may be expressed by macrophages in the inflamed tissue surrounding the injured artery.",

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year = "1996",

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T1 - Increased non-angiotensin II [125I]CGP 42112 binding in rat carotid artery after balloon injury

AU - Viswanathan, M

AU - Jöhren, O

AU - de Oliveira, M

AU - Saavedra, J M

PY - 1996

Y1 - 1996

N2 - In this study, [125I]CGP 42112, a ligand of high affinity and selectivity for the angiotensin II AT2 receptor, was used to detect and quantify a non-angiotensin II binding site in the balloon-injured carotid artery of the rat. The amount of [125I]CGP 42112 binding was significantly enhanced in the adventitia of the injured arteries. Localization of the binding site using emulsion autoradiography and immunocytochemistry suggests that the binding sites may be expressed by macrophages in the inflamed tissue surrounding the injured artery.

AB - In this study, [125I]CGP 42112, a ligand of high affinity and selectivity for the angiotensin II AT2 receptor, was used to detect and quantify a non-angiotensin II binding site in the balloon-injured carotid artery of the rat. The amount of [125I]CGP 42112 binding was significantly enhanced in the adventitia of the injured arteries. Localization of the binding site using emulsion autoradiography and immunocytochemistry suggests that the binding sites may be expressed by macrophages in the inflamed tissue surrounding the injured artery.

M3 - Journal articles

C2 - 8804082

SN - 0196-9781

VL - 17

SP - 695

EP - 699

JO - Peptides

JF - Peptides

IS - 4

ER -

Increased non-angiotensin II [125I]CGP 42112 binding in rat carotid artery after balloon injury

Abstract

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