TY - JOUR
T1 - Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome
AU - Niccolai, Valentina
AU - van Dijk, Hanneke
AU - Franzkowiak, Stephanie
AU - Finis, Jennifer
AU - Südmeyer, Martin
AU - Jonas, Melanie
AU - Thomalla, Götz
AU - Siebner, Hartwig Roman
AU - Müller-Vahl, Kirsten
AU - Münchau, Alexander
AU - Schnitzler, Alfons
AU - Biermann-Ruben, Katja
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome. Methods: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography. Results: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity. Conclusions: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity.
AB - Background: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome. Methods: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography. Results: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity. Conclusions: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity.
UR - http://www.scopus.com/inward/record.url?scp=84951982524&partnerID=8YFLogxK
U2 - 10.1002/mds.26454
DO - 10.1002/mds.26454
M3 - Journal articles
C2 - 26649991
AN - SCOPUS:84951982524
SN - 0885-3185
VL - 31
SP - 384
EP - 392
JO - Movement Disorders
JF - Movement Disorders
IS - 3
ER -
