Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome

Valentina Niccolai*, Hanneke van Dijk, Stephanie Franzkowiak, Jennifer Finis, Martin Südmeyer, Melanie Jonas, Götz Thomalla, Hartwig Roman Siebner, Kirsten Müller-Vahl, Alexander Münchau, Alfons Schnitzler, Katja Biermann-Ruben

*Corresponding author for this work
1 Citation (Scopus)


Background: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome. Methods: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography. Results: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity. Conclusions: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity.

Original languageEnglish
JournalMovement Disorders
Issue number3
Pages (from-to)384-392
Number of pages9
Publication statusPublished - 01.03.2016

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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