Incorporation of the α-mercapto acid unit into peptides

Ksenia Pumpor, Jan Spengler, Fernando Albericio*, Alois Haas, Klaus Burger

*Corresponding author for this work
3 Citations (Scopus)


Incorporation of α-mercapto acid units into the backbone of potential drug candidates improves the metal ion complexing properties. So far, only the methodology for the N-terminal incorporation of mercapto acid units into peptides has been described. Now, we report on a modified strategy for the incorporation of the α-mercapto acid unit into any position of a peptide backbone starting from hexafluoroacetone-protected thiomalic acid. Concomitantly with the incorporation of the α-mercapto unit the direction of the peptide chain is inverted.

Original languageEnglish
Issue number7
Pages (from-to)1088-1092
Number of pages5
Publication statusPublished - 06.05.2004

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


Dive into the research topics of 'Incorporation of the α-mercapto acid unit into peptides'. Together they form a unique fingerprint.

Cite this