Abstract
Incorporation of α-mercapto acid units into the backbone of potential drug candidates improves the metal ion complexing properties. So far, only the methodology for the N-terminal incorporation of mercapto acid units into peptides has been described. Now, we report on a modified strategy for the incorporation of the α-mercapto acid unit into any position of a peptide backbone starting from hexafluoroacetone-protected thiomalic acid. Concomitantly with the incorporation of the α-mercapto unit the direction of the peptide chain is inverted.
Original language | English |
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Journal | Synthesis |
Issue number | 7 |
Pages (from-to) | 1088-1092 |
Number of pages | 5 |
ISSN | 0039-7881 |
DOIs | |
Publication status | Published - 06.05.2004 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)