TY - JOUR
T1 - Incidence, target antigens, and clinical implications of antineutrophil cytoplasmic antibodies in rheumatoid arthritis
AU - Braun, Matthias Gerd
AU - Csernok, Elena
AU - Schmitt, Wilhelm Halvor
AU - Gross, Wolfgang Ludwig
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 1996/5
Y1 - 1996/5
N2 - Objective. To determine the incidence of antineutrophil cytoplasmic antibodies (ANCA) in rheumatold arthritis (RA), to detect the target antigens of ANCA, and to compare clinical and laboratory data of ANCA+ with ANCA- patients with RA. Methods. 385 sera of patients with RA were screened for ANCA by indirect immunofluorescence. ANCA+ sera were further analyzed for target antigens by ELISA. The ANCA+ patients were compared to randomly selected ANCA- patients with RA with respect to serological and radiological variables and extraarticular involvement. Results. ANCA were found in 16% of patients with RA (61/385 sera). All sera showed a perinuclear (pANCA) pattern. Antibodies directed against 5 different target antigens were found in 18/61 pANCA+ sera, antibodies directed against proteinase 3 were not observed. The analysis of ANCA+ and ANCA- patients revealed that the pANCA+ group exhibited significantly higher serological markers of inflammation (p < 0.005) and a higher incidence of rheumatoid factor (p < 0.005). Furthermore, vasculitic involvement was found at a higher frequency (p < 0.05) in the pANCA+ group. Five patients in the pANCA+ group had pulmonary involvement, but none in the pANCA-group. Conclusion. pANCA in RA may be a marker for a more aggressive course of disease in respect to serological variables and extraarticular manifestations including rheumatoid vasculitis and lung involvement.
AB - Objective. To determine the incidence of antineutrophil cytoplasmic antibodies (ANCA) in rheumatold arthritis (RA), to detect the target antigens of ANCA, and to compare clinical and laboratory data of ANCA+ with ANCA- patients with RA. Methods. 385 sera of patients with RA were screened for ANCA by indirect immunofluorescence. ANCA+ sera were further analyzed for target antigens by ELISA. The ANCA+ patients were compared to randomly selected ANCA- patients with RA with respect to serological and radiological variables and extraarticular involvement. Results. ANCA were found in 16% of patients with RA (61/385 sera). All sera showed a perinuclear (pANCA) pattern. Antibodies directed against 5 different target antigens were found in 18/61 pANCA+ sera, antibodies directed against proteinase 3 were not observed. The analysis of ANCA+ and ANCA- patients revealed that the pANCA+ group exhibited significantly higher serological markers of inflammation (p < 0.005) and a higher incidence of rheumatoid factor (p < 0.005). Furthermore, vasculitic involvement was found at a higher frequency (p < 0.05) in the pANCA+ group. Five patients in the pANCA+ group had pulmonary involvement, but none in the pANCA-group. Conclusion. pANCA in RA may be a marker for a more aggressive course of disease in respect to serological variables and extraarticular manifestations including rheumatoid vasculitis and lung involvement.
UR - http://www.scopus.com/inward/record.url?scp=0029977824&partnerID=8YFLogxK
M3 - Journal articles
C2 - 8724292
AN - SCOPUS:0029977824
VL - 23
SP - 826
EP - 830
JO - The Journal of rheumatology
JF - The Journal of rheumatology
SN - 0315-162X
IS - 5
ER -