Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder

Stefan Roepke; Andreas Ziegenhorn; Julia Kronsbein; Angela Merkl; Scharif Bahri; Julia Lange; Horst Lübbert; Ulrich Schweiger; Isabella Heuser; Claas H. Lammers

doi:10.1016/j.jpsychires.2010.01.007

Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder

Stefan Roepke^*, Andreas Ziegenhorn, Julia Kronsbein, Angela Merkl, Scharif Bahri, Julia Lange, Horst Lübbert, Ulrich Schweiger, Isabella Heuser, Claas H. Lammers

^*Corresponding author for this work

Department of Psychiatry, Psychosomatics and Psychotherapie

Charite - Universitatsmedizin Berlin

31 Citations (Scopus)

Abstract

Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.

Original language	English
Journal	Journal of Psychiatric Research
Volume	44
Issue number	13
Pages (from-to)	847-852
Number of pages	6
ISSN	0022-3956
DOIs	https://doi.org/10.1016/j.jpsychires.2010.01.007
Publication status	Published - 10.2010

Funding

This research was supported in part by a Grand from Charité-University Medicine Berlin. The funding sources had no role in this study’s design, in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Dr. Stefan Roepke has received research grants from Lilly and AstraZeneca. He has received teaching honoraries from Wyeth and AstraZeneca. Dr. Isabellla Heuser has received research grants from Jansen Cilag and Merz. She has advised Bayer Schering and has received teaching honoraries from Wyeth and Pfizer. Drs. Andreas Ziegenhorn, Julia Kronsbein, Angela Merkl, Scharif Bahri, Julia Lange, Horst Lübbert, Ulrich Schweiger, and Claas-H. Lammers report no conflict of interests.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1016/j.jpsychires.2010.01.007

Cite this

@article{f511da026d2f403a9247fa8986d36c8c,

title = "Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder",

abstract = "Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4\%) compared to healthy controls (6.9\%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.",

author = "Stefan Roepke and Andreas Ziegenhorn and Julia Kronsbein and Angela Merkl and Scharif Bahri and Julia Lange and Horst L{\"u}bbert and Ulrich Schweiger and Isabella Heuser and Lammers, \{Claas H.\}",

note = "Funding Information: This research was supported in part by a Grand from Charit{\'e}-University Medicine Berlin. The funding sources had no role in this study{\textquoteright}s design, in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Funding Information: Dr. Stefan Roepke has received research grants from Lilly and AstraZeneca. He has received teaching honoraries from Wyeth and AstraZeneca. Dr. Isabellla Heuser has received research grants from Jansen Cilag and Merz. She has advised Bayer Schering and has received teaching honoraries from Wyeth and Pfizer. Drs. Andreas Ziegenhorn, Julia Kronsbein, Angela Merkl, Scharif Bahri, Julia Lange, Horst L{\"u}bbert, Ulrich Schweiger, and Claas-H. Lammers report no conflict of interests. ",

year = "2010",

month = oct,

doi = "10.1016/j.jpsychires.2010.01.007",

language = "English",

volume = "44",

pages = "847--852",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Elsevier Ltd",

number = "13",

}

TY - JOUR

T1 - Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder

AU - Roepke, Stefan

AU - Ziegenhorn, Andreas

AU - Kronsbein, Julia

AU - Merkl, Angela

AU - Bahri, Scharif

AU - Lange, Julia

AU - Lübbert, Horst

AU - Schweiger, Ulrich

AU - Heuser, Isabella

AU - Lammers, Claas H.

N1 - Funding Information: This research was supported in part by a Grand from Charité-University Medicine Berlin. The funding sources had no role in this study’s design, in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Funding Information: Dr. Stefan Roepke has received research grants from Lilly and AstraZeneca. He has received teaching honoraries from Wyeth and AstraZeneca. Dr. Isabellla Heuser has received research grants from Jansen Cilag and Merz. She has advised Bayer Schering and has received teaching honoraries from Wyeth and Pfizer. Drs. Andreas Ziegenhorn, Julia Kronsbein, Angela Merkl, Scharif Bahri, Julia Lange, Horst Lübbert, Ulrich Schweiger, and Claas-H. Lammers report no conflict of interests.

PY - 2010/10

Y1 - 2010/10

N2 - Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.

AB - Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.

UR - https://www.scopus.com/pages/publications/77956344711

U2 - 10.1016/j.jpsychires.2010.01.007

DO - 10.1016/j.jpsychires.2010.01.007

M3 - Journal articles

C2 - 20149393

AN - SCOPUS:77956344711

SN - 0022-3956

VL - 44

SP - 847

EP - 852

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 13

ER -

Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder

Abstract

Funding

UN SDGs

Research Areas and Centers

Access to Document

Other files and links

Fingerprint

Cite this