TY - JOUR
T1 - Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder
AU - Roepke, Stefan
AU - Ziegenhorn, Andreas
AU - Kronsbein, Julia
AU - Merkl, Angela
AU - Bahri, Scharif
AU - Lange, Julia
AU - Lübbert, Horst
AU - Schweiger, Ulrich
AU - Heuser, Isabella
AU - Lammers, Claas H.
N1 - Funding Information:
This research was supported in part by a Grand from Charité-University Medicine Berlin. The funding sources had no role in this study’s design, in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Funding Information:
Dr. Stefan Roepke has received research grants from Lilly and AstraZeneca. He has received teaching honoraries from Wyeth and AstraZeneca. Dr. Isabellla Heuser has received research grants from Jansen Cilag and Merz. She has advised Bayer Schering and has received teaching honoraries from Wyeth and Pfizer. Drs. Andreas Ziegenhorn, Julia Kronsbein, Angela Merkl, Scharif Bahri, Julia Lange, Horst Lübbert, Ulrich Schweiger, and Claas-H. Lammers report no conflict of interests.
PY - 2010/10
Y1 - 2010/10
N2 - Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.
AB - Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17α-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.
UR - http://www.scopus.com/inward/record.url?scp=77956344711&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2010.01.007
DO - 10.1016/j.jpsychires.2010.01.007
M3 - Journal articles
C2 - 20149393
AN - SCOPUS:77956344711
SN - 0022-3956
VL - 44
SP - 847
EP - 852
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 13
ER -
